Results 91 to 100 of about 4,379,222 (227)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Anuario del Seminario de Filología Vasca "Julio de Urquijo", 2018 The Basque evidential particle omen is very interesting for bascologists (Basque linguists) and Basque translators. For linguists, due to the fact that the two neighboring languages (Spanish and French) lack a similar particle, and for translators ...
Karlos Cid Abasolo
doaj
Evidential multi-model CNN integration for visual fault detection in solar panels
Next EnergyThis study proposes an evidential fusion framework for classifying visual defects in solar panels using convolutional neural networks (CNNs) and Dempster-Shafer theory (DST). Three pretrained CNN models: ResNet50, MobileNetV2, and EfficientNetB0 are fine-
Nadjia Khatir, Safia Nait-Bahloul
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An idea whose time has come: Strategies for Youth 2016 annual report [PDF]
, 2017 This report outlines techniques for training police officers to interact with youth in ways that reduce the number of ...
Strategies for Youth
core
The use of the "omen" particle and its equivalents in Spanish: The case of Anjel Lertxundi
Anuario del Seminario de Filología Vasca "Julio de Urquijo", 2018 The Basque evidential particle omen is very interesting for bascologists (Basque linguists) and Basque translators. For linguists, due to the fact that the two neighboring languages (Spanish and French) lack a similar particle, and for translators ...
Karlos Cid Abasolo
doaj
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Nomination and Argumentation Strategies in Oratory Discourse: The Case of an English Sermon
SAGE Open, 2017 Inspired by critical discourse analysis and regarding language as a social medium whereby individuals, social groups, and institutions tend to express their beliefs and values, this study seeks to explore the persuasion and discourse strategies utilized ...
Sara Mansouri +3 more
doaj +1 more source