Results 101 to 110 of about 39,995 (281)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
How could a rational analysis model explain? [PDF]
, 2017 Rational analysis is an influential but contested account of how probabilistic modeling can be used to construct non-mechanistic but self-standing explanatory models of the mind.
Reijula, Samuli
core +1 more source
Anuario del Seminario de Filología Vasca "Julio de Urquijo", 2018 The Basque evidential particle omen is very interesting for bascologists (Basque linguists) and Basque translators. For linguists, due to the fact that the two neighboring languages (Spanish and French) lack a similar particle, and for translators ...
Karlos Cid Abasolo
doaj
Evidential multi-model CNN integration for visual fault detection in solar panels
Next EnergyThis study proposes an evidential fusion framework for classifying visual defects in solar panels using convolutional neural networks (CNNs) and Dempster-Shafer theory (DST). Three pretrained CNN models: ResNet50, MobileNetV2, and EfficientNetB0 are fine-
Nadjia Khatir, Safia Nait-Bahloul
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Peter Boghossian, A Manual for Creating Atheists [PDF]
, 2014 Book review of Peter Boghossian, A Manual for Creating Atheists, Pitchstone Publishing, 2013, 280pp., $14.95, ISBN 978-1939578099 (paperback). Foreword by Michael Shermer.
Repetti, Rick
core
The use of the "omen" particle and its equivalents in Spanish: The case of Anjel Lertxundi
Anuario del Seminario de Filología Vasca "Julio de Urquijo", 2018 The Basque evidential particle omen is very interesting for bascologists (Basque linguists) and Basque translators. For linguists, due to the fact that the two neighboring languages (Spanish and French) lack a similar particle, and for translators ...
Karlos Cid Abasolo
doaj
Nomination and Argumentation Strategies in Oratory Discourse: The Case of an English Sermon
SAGE Open, 2017 Inspired by critical discourse analysis and regarding language as a social medium whereby individuals, social groups, and institutions tend to express their beliefs and values, this study seeks to explore the persuasion and discourse strategies utilized ...
Sara Mansouri +3 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source