The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Is stylistics a hard science? Intersubjective positioning in Language and Literature research article abstracts between 2013 and 2022. [PDF]
Alaghbary GS.
europepmc +1 more source
PICALM::MLLT10 translocated leukemia
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
The Construction of National Image of China by English World Media in Public Health Emergencies.
Zhang D.
europepmc +1 more source
Some General Remarks on Interactions between Aspect, Modality,and Evidentiality in Biblical Hebrew [PDF]
Holger Gzella
openalex
Estilos de vida y función vascular. Estudio EVIDENT
José I. Recio-Rodríguez
openalex +1 more source
The delay of shock breakout due to circumstellar material evident in most type II supernovae [PDF]
F. Förster +37 more
openalex +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Are Late-Born Young Soccer Players Less Mature Than Their Early-Born Peers, Although No Differences in Physical and Technical Performance Are Evident? [PDF]
Eduard Bezuglov +7 more
openalex +1 more source
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source

