Results 81 to 90 of about 3,788 (240)
Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance
Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah +5 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Intersubjective strategies in deontic modality: evidential functions of Spanish deber ‘must’
Kalbotyra, 2017 The principal aim of this study is to examine the Spanish modal verb deber ‘must’ in its deontic readings, relating it to the notions of evidentiality and intersubjectivity.
Miriam Thegel
doaj +1 more source
Yauyos Quechua Evidentials And Evidential Modifiers
, 2012 This paper examines the evidential system of the five southern dialects of Yauyos, a previously undocumented, extremely endangered Quechuan language of Peru. The paper looks at Yauyos' unusual system of evidential modification and its effects on the interpretation of mode, particularly in conjunction with the language's ...
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2018 [Extract] There are, in every language, means for saying how one knows what one is talking about, and what one thinks about what one knows or has learnt.
Aikhenvald, Alexandra Y.
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Kalbotyra, 2017 Most research on evidentiality has focused on classifying evidential systems synchronically; meanwhile, diachronic studies on evidentiality seem to have focused on the development of specific items into evidential markers with little regard to discourse ...
Richard J. Whitt
doaj +1 more source