Results 101 to 110 of about 790,565 (357)

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

open access: yesAdvanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang   +8 more
wiley   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma   +15 more
wiley   +1 more source

"See no evil, hear no evil, speak no evil"

open access: yes, 2018
A PBS documentary synthetizes Donald Trump’s comments about his belief that some people are genetically superior than others. The eugenic ideal is the antithesis of the self-made man American value and is a controversial view among Deaf Americans that still remember the work of Alexander Graham Bell.
openaire   +2 more sources

The Limits of Theodicy: An Eastern Orthodox Perspective on Evil and Interreligious Theology [PDF]

open access: yes, 2016
This essay is written from the vantage point of a comparative theologian who is personally steeped in the Eastern Orthodox Christian tradition and who primarily specializes in Christian-Muslim comparative theology.
Monge, Rico G.
core   +3 more sources

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang   +7 more
wiley   +1 more source

On justifications and excuses [PDF]

open access: yes, 2017
The New Evil Demon problem has been hotly debated since the case was introduced in the early 1980’s (e.g. Lehrer and Cohen 1983; Cohen 1984), and there seems to be recent increased interest in the topic.
Madison, B. J. C.
core  

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

open access: yesAdvanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma   +10 more
wiley   +1 more source

Motif of Justice in The Revenger’s Tragedy A Close Study of Revenge and Justice in Cyril Tourneur’s The Revenger’s Tragedy [PDF]

open access: yesTeaching English Language, 2007
The genre of revenge tragedy has been an obsession with most writers throughout literature of different ages, starting from ancient Greek drama as seen in the works of three major tragedians, Aeschyus, Sophocles and Euripides and later dominant in the ...
Maryam Beyad
doaj  

Sin: Radical Evil in Soul and Society [PDF]

open access: yes, 1996
Reviewed Book: Peters, Ted. Sin: Radical Evil in Soul and Society.
Trudeau, Juliette
core   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

open access: yesAdvanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang   +17 more
wiley   +1 more source

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