Results 121 to 130 of about 853,340 (351)
On justifications and excuses [PDF]
, 2017 The New Evil Demon problem has been hotly debated since the case was introduced in the early 1980’s (e.g. Lehrer and Cohen 1983; Cohen 1984), and there seems to be recent increased interest in the topic.
Madison, B. J. C.
core
Advanced Science, EarlyView.TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng +9 more
wiley +1 more source
See No Evil: Cognitive Challenges of Security Surveillance and Monitoring
, 2017 While the development of intelligent technologies in security surveillance can augment human capabilities, they do not replace the role of the operator entirely; as such, when developing surveillance support it is critical that limitations to the ...
H. Hodgetts +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan +8 more
wiley +1 more source
Evil and Human Suffering in Islamic Thought—Towards a Mystical Theodicy
, 2018 This paper sheds light on the treatment of the ‘problem of evil’ and human suffering from an Islamic perspective. I begin by providing an overview of the term ‘evil’ in the Qur’an to highlight its multidimensional meaning and to demonstrate the overall ...
Nasrin Rouzati
semanticscholar +1 more source
Advanced Science, EarlyView.Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma +10 more
wiley +1 more source
Escape from Evil? Notes on Capacity, Tragedy, Coding and Non-Destructive Immortality Projects
Oñati Socio-Legal Series, 2014 Like James Hardie-Bick’s (2015) contribution this paper elaborates on the importance for socio-legal studies of Ernest Becker’s (1924-1974) work on the destructive consequences of human … all too human forms of death denial.
Ronnie Lippens
doaj
The Resolution of the Problem of Evil in the Works of Àyatullah Jawadi Àmuli [PDF]
حکمت اسرا, 2010 The ontological and epistemological roots of evil and the relevance of the problem to the divine essence, attributes and acts, has always warranted the attention of thinkers and intellectuals.
Muslim Muhammadi
doaj
Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Advanced Science, EarlyView.Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang +17 more
wiley +1 more source
Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro
Advanced Science, EarlyView.A new biphasic in vitro cryogel/hydrogel model of early breast cancer bone metastasis provides precise control over microenvironmental cues and microscopic access to the spatiotemporal cancer cell distribution. Deposited bone‐like mineral is observed to strongly impede the effects of biomolecular signals, as evidenced by both colonization profiles and ...
Jana Sievers‐Liebschner +8 more
wiley +1 more source