Results 71 to 80 of about 67,758 (305)

Dopamine inactivation efficacy related to functional DAT1 and COMT variants influences motor response evaluation [PDF]

, 2012
BACKGROUND: Dopamine plays an important role in orienting, response anticipation and movement evaluation. Thus, we examined the influence of functional variants related to dopamine inactivation in the dopamine transporter (DAT1) and catechol-O ...
Laucht, Manfred (Prof. Dr.), Rellum Thomas, Thomas Rellum, Resch, Franz, Stephan Bender, Brandeis, Daniel, Banaschewski, Tobias, Laucht Manfred, Bender, Stephan, Rietschel, Marcella, Jennen-Steinmetz, Christine, Freitag, Christine M., Treutlein, Jens, Jens Treutlein, Rellum, Thomas, Daniel Brandeis, Brandeis Daniel, Tobias Banaschewski, Jennen-Steinmetz Christine, Christine Freitag, Bender Stephan, Banaschewski Tobias, Manfred Laucht, Freitag, Christine, Franz Resch, Rietschel Marcella, Marcella Rietschel, Resch Franz, Christine Jennen-Steinmetz, Laucht, Manfred, Treutlein Jens, Freitag Christine   +31 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Transcranial magnetic motor evoked potentials and magnetic resonance imaging findings in paraplegic dogs with recovery of motor function. [PDF]

, 2018
BACKGROUND: Transcranial magnetic motor evoked potentials (TMMEP) are associated with severity of clinical signs and magnetic resonance imaging (MRI) findings in dogs with spinal cord disease.
Stein, Veronika Maria, Rohn, K, Tipold, A, Johannes S. Siedenburg, Wang-Leandro, A, Amendt, HL, Andrea Tipold, Veronika M. Stein, Adriano Wang-Leandro, Karl Rohn, Siedenburg, JS, Hanna-Luise Amendt   +11 more
core   +1 more source

Effects of transcranial alternating current stimulation on neurophysiologic motor function in Parkinson’s patients: a systematic review and meta-analysis

Frontiers in Aging Neuroscience
ObjectiveThis systematic review and meta-analysis aimed to evaluate whether tACS improves neurophysiologic motor function in patients with Parkinson’s patients.MethodsWe searched PubMed, Embase, Web of Science, and Cochrane Library for eligible studies ...
Fangcheng Ye, Yinjin Shao, Yinjin Shao, Guihua Wu, Guihua Wu, Miao Huang, Miao Huang, Hui Huang, Hui Huang   +8 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Towards improved visual stimulus discrimination in an SSVEP BCI

, 2010
The dissertation investigated the influence of stimulus characteristics, electroencephalographic (EEG) electrode location and three signal processing methods on the spectral signal to noise ratio (SNR) of Steady State Visual Evoked Potentials (SSVEPs ...
Hodgskiss, Dean Leslie
core  

Reliability of Motor Evoked Potentials Induced by Transcranial Magnetic Stimulation: The Effects of Initial Motor Evoked Potentials Removal

Basic and Clinical Neuroscience, 2017
Introduction: Transcranial magnetic stimulation (TMS) is a useful tool for assessment of corticospinal excitability (CSE) changes in both healthy individuals and patients with brain disorders. The usefulness of TMS-elicited motor evoked potentials (MEPs)
Fahimeh Hashemirad, Maryam Zoghi, Paul B Fitzgerald, Shapour Jaberzadeh   +3 more
doaj  

Magnetic Motor Evoked Potentials in Ponies

Journal of Veterinary Internal Medicine, 1996
Abstarct Magnetic stimulation of motor pathways was used to effect motor unit action potential recordings from forelimb and hindlimb muscles in unanesthetized ponies. Motor pathway conduction velocities to the forelimb and hindlimb were determined to be 53.8 ± 9.6 m/s-1 and 63.4 ± 8.3 m/s-1, respectively.
I G, Mayhew, J R, Washbourne
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]

, 1982
The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Ten Bruggencate, Gerrit, Galvan, Martin, Grafe, Peter   +2 more
core   +1 more source