Results 121 to 130 of about 180,175 (329)

Reflections on Consciousness in Intensive Care

Acta Paediatrica, EarlyView.
ABSTRACT Evaluating consciousness in intensive care is pivotal to relieving suffering with analgesic or sedative drugs and in prognosis and diagnoses. The usual clinical perspective is to equate consciousness with responsiveness, assuming functional motor responses and sympathetic activity of the patient. Clinical diagnoses of coma may be wrong in more
Michael Broomé, Tiit Mathiesen
wiley   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker

British Journal of Pharmacology, EarlyView.
Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez, Almudena Iñigo‐Portugués, Enrique Velasco, Susana Quirce, Fernando Aleixandre‐Carrera, Ariadna Díaz‐Tahoces, M. Carmen Acosta, Wan‐Chen Lin, Richard H. Kramer, Carlos Belmonte, Juana Gallar, Victor Meseguer   +11 more
wiley   +1 more source

Task-dependent Modulation of Cortical Excitability and Balance Control in Individuals with Post-concussion Syndrome [PDF]

, 2017
In most cases, symptoms resolve between 7-10 days post-concussion. However, in 10-15% of the concussed population, symptoms can remain unresolved for months to years following the head injury.
Cinelli, Michael E, Mr, Kalmar, Jayne M, Ms., Kaster, Kristen   +2 more
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Visual and somatosensory evoked potentials abnormalities among Behçet’s disease patients and their relation to disease activity, severity and antiphospholipid antibodies: a cross-sectional study

Egyptian Rheumatology and Rehabilitation
Background Behçet’s disease (BD) is a common disease with high morbidity and mortality. Ocular, neurological, and vascular affection in BD are a major cause of such morbidity and mortality. Evoked potential (EP) studies including visual evoked potentials
Ghada S. Nageeb, Enass A. Eliwa, Ibrahim Tharwat, Lamiaa A. Mohammad, Nada Alaa Attia   +4 more
doaj   +1 more source

NeuroSense: A non-invasive and configurable somatosensory stimulator with OPENVIBE communication

HardwareX
Understanding the somatosensory system and its abnormalities requires the development of devices that can accurately stimulate the human skin. New methods for assessing the somatosensory system can enhance the diagnosis, treatments, and prognosis for ...
Erick A. Gonzalez-Rodriguez, Luis Kevin Cepeda-Zapata, Angel Antonio Rivas-Silva, Vania G. Martinez-Gonzalez, Luz Maria Alonso-Valerdi, David Isaac Ibarra-Zarate   +5 more
doaj   +1 more source

Investigation of effects of two environmental heavy metals in a combined exposure model on the nervous system in rats [PDF]

, 2012
In the present study, the interaction of inhalational and oral exposure to manganese and lead was investigated. Young adult male Wistar rats (2 x 10 per group) were treated orally with MnCl2 (15 and 60 mg/kg b.w.) or Pb acetate (80 and 320 mg/kg) for 3 ...
Horváth, Edina, Máté, Zsuzsanna, Papp, András, Szabó, Andrea   +3 more
core  

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, EarlyView.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source