Results 181 to 190 of about 26,311 (257)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, Volume 13, Issue 39, 13 July 2026.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

The performance of mind: from movement, mental states, and consciousness. [PDF]

Front Psychol
Cheron G, Cebolla AM.
europepmc   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

A Corticotectal Pathway Regulates Vibrissal Somatosensory-Mediated Predatory Hunting Learning. [PDF]

Research (Wash D C)
Li Y, Chen G, Geng D, Zheng R, Xie Z, Zhang T, Cao P, Zhang F.   +7 more
europepmc   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, Volume 13, Issue 40, 17 July 2026.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Intraoperative neurophysiological monitoring versus no monitoring in intradural extramedullary tumor surgery: a systematic review and meta-analysis of early postoperative neurological outcomes. [PDF]

Neurosurg Rev
Correa EM, Lopes O, Carrion A, de Oliveira Ferreira DBC, Divério G, Ferreira-Pinto PHC, Nigri F.   +6 more
europepmc   +1 more source

Prolonged systemic inflammation worsens impairments to astrocyte Ca2+ and functional hyperemia in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Chronic neuroinflammation in Alzheimer's disease (AD) alters astrocyte physiology and neurovascular unit function. AD patients frequently experience recurrent systemic inflammatory insults from comorbid conditions, which act as “secondary‐hits” believed to worsen cognitive decline.
Chang Liu, Kimia Sakha, Jaime Anton, Alfredo Cardenas‐Rivera, Mohammad A. Yaseen   +4 more
wiley   +1 more source

Ventrolateral pontomedullary junction cavernous malformation: illustrative case. [PDF]

J Neurosurg Case Lessons
Huang C, Bao Y.
europepmc   +1 more source

An elastic segment of the whisker shaft enables coding of the whisking phase via whisker torsion in rats and mice

The Anatomical Record, Volume 309, Issue 7, Page 1910-1924, July 2026.
An elastic segment was found in the basal part of the whisker shaft in rats and mice. Application of force to the whisker bulb of isolated follicles caused bending and twisting of this segment. Active whisker movements deform this segment, causing whisker shaft deflection and selective activation of mechanoreceptors at different phases of whisking ...
Sebastian Haidarliu, Guy Nelinger, Luka Gantar, Ehud Ahissar, Inbar Saraf‐Sinik   +4 more
wiley   +1 more source