Activated microglia‐derived inflammatory signals drive astrocytic Piezo1 expression in both in vitro and in vivo models. Piezo1 upregulation modulates astrocytic Ca2+ dynamics and inflammatory gene expression, thereby limiting microglial activation. ABSTRACT Structural tissue alterations in numerous brain disorders can initiate mechanosensory signaling
Yanyang Bai +8 more
wiley +1 more source
Dermatomal Contact Heat Evoked Potentials for the Detection of Subclinical Cervical Spinal Cord Injury in Asymptomatic Degenerative Cervical Cord Compression. [PDF]
Joppekova L +11 more
europepmc +1 more source
Auditory Stimulation of Slow‐Wave Sleep Promotes Recovery after Brain Injury in an Animal Model
Objective Traumatic brain injury (TBI) significantly reduces the quality of life for millions of survivors worldwide, causing persistent brain tissue damage and cognitive impairments, with no established therapeutic interventions currently available.
Carlos G. Moreira +9 more
wiley +1 more source
Changes in Intrinsic Activity of the Primary Somatosensory Cortex Causally Explain Differences in Emotion Perception in Autism. [PDF]
Fanghella M +5 more
europepmc +1 more source
In this study, we propose a multiscale spatiotemporal causal mapping (MSTCM) algorithm integrating multiscale functional connectivity and delay‐aware causal inference. Applied to resting‐state fMRI data, MSTCM reveals that taVNS reorganizes large‐scale brain networks by enhancing global integration efficiency while shifting information processing from ...
Weiyi Wang +5 more
wiley +1 more source
Somatosensory input drives membrane potential dynamics in motor cortex during voluntary limb movement. [PDF]
Voigt BC +3 more
europepmc +1 more source
The Laryngeal Auditory Startle Reflex (LASR): A New Component of the Auditory Startle Response
The auditory startle reflex contains a distinct laryngeal component, termed the laryngeal auditory startle reflex (LASR). In healthy adults, the LASR is modulated by supratentorial influences and habituates to repetitive stimuli. Physiologic and pathologic implications for the LASR as a component of the overall human SR remain to be determined but may ...
Catherine F. Sinclair +4 more
wiley +1 more source
Unraveling seizure interruptions: Excitability dynamics in spike-wave activity. [PDF]
van Luijtelaar G, de Ruijter B.
europepmc +1 more source
Revisiting Controversial Areas in the Management of Premature Ejaculation
ABSTRACT The cause of premature ejaculation (PE) is often multifactorial in nature, and effective management of PE is complex and should involve multimodal approaches. This narrative review examines the ongoing controversies surrounding key areas in the diagnosis and treatment of PE with an emphasis on future research directions to align clinical care ...
Dong Sup Lee +6 more
wiley +1 more source
Improving Diagnostic Accuracy for Peripheral Neuropathy: Use of Tibial Nerve Somatosensory Evoked Potentials. [PDF]
Oka M +10 more
europepmc +1 more source

