Results 31 to 40 of about 356,019 (243)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Refueling the Magic Furnace: Kilonova 2017 Rewrites the Story of Element Origins

Journal of Big History, 2018
For more than half a century, we have understood element creation in the stars—described in Marcus Chown’s colorful image as “the magic furnace.” From 1958 until 2017, supernova explosions were thought to be the primary site of element creation above ...
Barry Woods
doaj   +1 more source

High-throughput library transgenesis in Caenorhabditis elegans via Transgenic Arrays Resulting in Diversity of Integrated Sequences (TARDIS)

eLife, 2023
High-throughput transgenesis using synthetic DNA libraries is a powerful method for systematically exploring genetic function. Diverse synthesized libraries have been used for protein engineering, identification of protein–protein interactions ...
Zachary C Stevenson, Megan J Moerdyk-Schauwecker, Stephen A Banse, Dhaval S Patel, Hang Lu, Patrick C Phillips   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Four terpene synthases contribute to the generation of chemotypes in tea tree (Melaleuca alternifolia)

BMC Plant Biology, 2017
Background Terpene rich leaves are a characteristic of Myrtaceae. There is significant qualitative variation in the terpene profile of plants within a single species, which is observable as “chemotypes”.
Amanda Padovan, Andras Keszei, Yasmin Hassan, Sandra T. Krause, Tobias G. Köllner, Jörg Degenhardt, Jonathan Gershenzon, Carsten Külheim, William J. Foley   +8 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Chemical evolution and life

BIO Web of Conferences, 2015
In research on the origins of life, the concept of “chemical evolution” aims at explaining the transition from non-living matter to living matter.
Malaterre Christophe
doaj   +1 more source

Transcriptional and proteomic analysis of the innate immune response to microbial stimuli in a model invertebrate chordate

Frontiers in Immunology, 2023
Inflammatory response triggered by innate immunity can act to protect against microorganisms that behave as pathogens, with the aim to restore the homeostatic state between host and beneficial microbes.
Assunta Liberti, Carla Pollastro, Gabriella Pinto, Gabriella Pinto, Anna Illiano, Anna Illiano, Rita Marino, Angela Amoresano, Angela Amoresano, Antonietta Spagnuolo, Paolo Sordino   +10 more
doaj   +1 more source

CHEMICAL EVOLUTION [PDF]

, 1965
How did life come to be on the surface of the earth? Darwin himself recognized that his basic idea of evolution by variation and natural selection must be a continuous process extending backward in time through that period in which the first living things arose and into the period of 'Chemical Evolution' which preceded it.
openaire   +2 more sources