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The Molecular Evolution of Trypanosomes
Parasitology Today, 1999The absence of a fossil record has meant that the evolution of protozoa has remained largely a matter for speculation. Recent advances in molecular biology and phylogenetic analysis, however, are allowing the 'history written in the genes' to be interpreted. Here, Jamie Stevens and Wendy Gibson review progress in reconstruction of trypanosome phylogeny
Stevens, JR, Gibson, WC
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General and Comparative Endocrinology, 2001
Leptin, a hormone produced mainly by adipocytes, is involved in the regulation of food intake, metabolism, and reproduction. The objective of this study was to determine the evolutionary relationships of leptin genes. Partial nucleotide sequences of leptin were cloned and sequenced from six mammalian species: large hairy armadillo (Chaetophractus ...
Vance L. Trudeau +3 more
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Leptin, a hormone produced mainly by adipocytes, is involved in the regulation of food intake, metabolism, and reproduction. The objective of this study was to determine the evolutionary relationships of leptin genes. Partial nucleotide sequences of leptin were cloned and sequenced from six mammalian species: large hairy armadillo (Chaetophractus ...
Vance L. Trudeau +3 more
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Molecular Evolution of Adenoviruses [PDF]
, 2003 New advances in the field of genetic characterization of adenoviruses originating from different animal species are summarized. Variations seen in the host range and specificity, pathogenicity, genomic arrangement or gene complement are much wider than expected based on previous studies of human adenoviruses.
Mária Benko, Balázs Harrach
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Molecular evolution in bacteria [PDF]
Antonie van Leeuwenhoek, 1995 Recent advances in microbiology and molecular biology have a unifying influence on our understanding of genetic diversity/similarity and evolutionary relationships in microorganisms. This article attempts to unify information from diverse areas such as microbiology, molecular biology, microbial physiology, clay crystal genes, metals-microbe-clay ...
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Molecular Evolution of Catalysis
Journal of Theoretical Biology, 2000In this paper, we consider the evolutionary dynamics of catalytically active species with a distinct genotype-phenotype relationship. Folding landscapes of RNA molecules serve as a paradigm for this relationship with essential neutral properties. The landscape itself is partitioned by phenotypes (realized as RNA secondary structures). To each genotype (
Christian V. Forst, Christian V. Forst
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Molecular evolution and optimization
Antonie van Leeuwenhoek, 1997Microbial populations (and life) not only evolve, they optimize. The transition from a random, unorganized, lifeless Earth to the present situation, where the Earth is virtually covered with nucleic acids and diverse and complex species, required numerous molecular changes and the integration of metabolic pathways over billions of years.
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On the rate of molecular evolution
Journal of Molecular Evolution, 1971There are at least two outstanding features that characterize the rate of evolution at the molecular level as compared with that at the phenotypic level. They are; (1) remarkable uniformity for each molecule, and (2) very high overall rate when extrapolated to the whole DNA content.
Tomoko Ohta, Motoo Kimura
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Disciplining molecular evolution
Trends in Ecology & Evolution, 1998Molecular Evolution by W-H. Li Sinauer, 1997. £32.95 hbk (xv+487 pages) ISBN 0 87893 463 4.
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The molecular evolution of trypanosomatidae
2001In the absence of a fossil record, theories relating to the evolution of protozoa have, for most of the twentieth century, been based on morphological and life cycle data despite their known limitations. However, recent advances in molecular methodology, notably the wide availability of accurate, automated DNA sequencing, have made it possible to ...
Wendy Gibson +3 more
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Molecular Evolution of Proteasomes
2002Proteasomes are large, multisubunit proteases that are found, in one form or another, in all domains of life and play a critical role in intracellular protein degradation. Although they have substantial structural similarity, the proteasomes of bacteria, archaea, and eukaryotes show many differences in architecture and subunit composition. This article
Andrei N. Lupas, Craig Volker
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