Results 181 to 190 of about 653,804 (199)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Investigating adaptation to environmental variability in forest trees through molecular phylogenetic analysis. [PDF]

PLoS One
Garosi C, Vettori C, Ferrante R, Paffetti D.   +3 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Chirality-Induced Orbital-Angular-Momentum Selectivity in Electron Transmission and Scattering. [PDF]

J Chem Theory Comput
Chen Y, Hod O, Gersten J, Nitzan A.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Correction to: UPrimer: A Clade-Specific Primer Design Program Based on Nested-PCR Strategy and Its Applications in Amplicon Capture Phylogenomics. [PDF]

Mol Biol Evol
europepmc   +1 more source

Models and observational predictions of dust traps in protoplanetary discs. [PDF]

Astrophys Space Sci
Pinilla P.
europepmc   +1 more source

Molecular Dynamics Simulation of Nano-Aluminum: A Review on Oxidation, Structure Regulation, and Energetic Applications. [PDF]

Nanomaterials (Basel)
Ouyang D, Chen X, Zhang Q, Yu C, Cheng H, Pang W, Qiu J.   +6 more
europepmc   +1 more source

Adaptive tracking with antagonistic pleiotropy results in seemingly neutral molecular evolution. [PDF]

Nat Ecol Evol
Song S, Chen P, Shen X, Zhang J.
europepmc   +1 more source