Results 111 to 120 of about 880,221 (312)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

A continuous evolution system for contracting the host range of bacteriophage T7. [PDF]

open access: yesSci Rep, 2020
Holtzman T   +5 more
europepmc   +1 more source

The Evolution of Production Systems

open access: yesAnnals of Business Administrative Science, 2012
This paper analyzes the formation process of production systems in order to identify the sources of Toyota’s competitive strength (i.e., its long-term high-level performance). While previous studies have analyzed either the functions of the Toyota-style manufacturing system or the history of that system, there have been few research efforts that have ...
openaire   +4 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

A Lagrangian Snow-Evolution System for Sea-Ice Applications (SnowModel-LG): Part I-Model Description. [PDF]

open access: yesJ Geophys Res Oceans, 2020
Liston GE   +7 more
europepmc   +1 more source

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