Results 111 to 120 of about 463,791 (292)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Existence and convergence theorems for evolutionary hemivariational inequalities of second order

Electronic Journal of Differential Equations, 2015
This article concerns with a class of evolutionary hemivariational inequalities in the framework of evolution triple. Based on the Rothe method, monotonicity-compactness technique and the properties of Clarke's generalized derivative and gradient, the
Zijia Peng, Cuie Xiao
doaj  

The Multiple Origin of Blue Straggler Stars: Theory vs. Observations

, 2014
In this chapter we review the various suggested channels for the formation and evolution of blue straggler stars (BSSs) in different environments and their observational predictions.
A. Hypki, A. Jorissen, A. M. Geller, A. M. Geller, A. M. Geller, A. S. Hamers, A. Tokovinin, B. W. Carney, B. W. Carney, C. Abate, D. Fabrycky, D. Raghavan, D. T. F. Weldrake, D. T. F. Weldrake, D. W. Latham, F. Antonini, F. R. Ferraro, F. R. Ferraro, H. B. Perets, H. B. Perets, H. B. Perets, H. B. Perets, J. G. Hills, J. M. Fregeau, J. M. Nemec, J. R. Hurley, L. G. Kiseleva, L. Lovisi, L. Lovisi, M. Auriere, M. B. Davies, M. L. Lidov, M. M. Shara, M. Mapelli, M. Mateo, N. Leigh, N. Leigh, P. Eggleton, P. J. T. Leonard, P. J. T. Leonard, P. J. T. Leonard, P. J. T. Leonard, P. J. T. Leonard, P. P. Eggleton, P. P. Eggleton, R. D. Mathieu, R. D. McClure, R. Kippenhahn, R. S. Harrington, S. Chatterjee, S. M. Rucinski, T. Dermine, T. Mazeh, W. Benz, W. H. McCrea, W. H. McCrea, W. I. Clarkson, W. Landsman, X. Chen, Y. Kozai   +59 more
core   +1 more source

Numerical Evolution of Single, Binary and Triple Stars [PDF]

Proceedings of the International Astronomical Union, 2007
AbstractI discuss my stellar evolution code Ev in the context of simulations of large clusters of stars. It has long been able to handle single stars, and also binary stars up to a point. That point is far beyond what other codes are able to do, but well short of what is necessary for believable simulations. A recent version, Ev(Twin), can in principle
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Tunnel spectroscopy in ac-driven quantum dot nanoresonators

, 2008
Electronic transport in a triple quantum dot shuttle device in the presence of an ac field is analyzed within a fully quantum mechanical framework.
Cota, E., Maldonado, I., Platero, G., Sánchez, R., Villavicencio, J.   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source