Results 91 to 100 of about 79,392 (261)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A New High‐Resolution Broadband Lg Attenuation Model Beneath Colombia: Implications for Triple Junction Tectonics

Geophysical Research Letters
The existence of a typical triple junction in Colombia is crucial for understanding plate convergence and coupling among the South American Plate, the subducting Nazca Plate, and the Caribbean Plate.
Zhen Liu, Lian‐Feng Zhao, Xiao‐Bi Xie, Carlos A. Vargas, Bao‐Feng Tian, Zhen‐Xing Yao   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The Triple Evolution Theory (ATTHE)

The Triple Evolution Theory (ATTHE) is an original intellectual work developed by Walid Hassan Al-Ashwah. It proposes a novel spiral model of conscious evolution, sustainable transformation, and creative development. The theory introduces original laws, including the Law of Cognitive Stagnation, the Principle of Ethical Governance, the Continuity of ...
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Novel Highly Pathogenic Avian Influenza A(H5N1) Virus, Argentina, 2025

Emerging Infectious Diseases
Genomic sequencing of reemerging highly pathogenic avian influenza A(H5N1) virus detected in Argentina in February 2025 revealed novel triple-reassortant viruses containing gene segments from Eurasian H5N1 and low pathogenicity viruses from South and ...
Ralph E.T. Vanstreels, Martha I. Nelson, María C. Artuso, Vanina D. Marchione, Luana E. Piccini, Estefania Benedetti, Alvin Crespo-Bellido, Agostina Pierdomenico, Thorsten Wolff, Marcela M. Uhart, Agustina Rimondi   +10 more
doaj   +1 more source

Stellar and dynamical evolution within triple systems

, 1995
About 5-15% of stellar systems are at least triple. About 1% of systems with a primary of $\tgs 1 \Mscun$ are triple with a {\it longer} peri od that is less than 30y, and so may in principle be capable of Roche-lobe overflow in both the inner and the outer orbits, at different times.
Eggleton, P. P., Kiseleva, L. G.
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Dynamical Origin of the Vertical Metallicity Gradient of the Milky Way Bulge

The Astrophysical Journal
A vertical metallicity gradient (VMG) in the Milky Way bulge is well-established. Yet, its origin has not been fully understood under the Galactic secular evolution scenario.
Bin-Hui Chen, Juntai Shen, Zhong Liu
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source