Results 81 to 90 of about 85,786 (301)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
On evolution of relatively large combinational logic circuits
, 2005 Evolvable hardware (EHW) (Yao and Higuchi, 1999) is a technique introduced to automatically design circuits where the circuit configuration is carried out by evolutionary algorithms.
Yatskevich, Y +9 more
core +1 more source
, 2020 Proposed is a methodology for an accurate description of triple junctions’ network evolution in the course of severe plastic deformation (SPD). It is based on representations of polycrystalline solids with discrete combinatorial complexes, processes ...
Borodin, E.N.; id_orcid +1 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011 To solve the stability problem of one-dimensional elements of construction on the border of different elastic ambiences the algorithm of motion on the parameter of one ambience is suggested.
E. I. Mikhailovskii, E. V. Tulubenskaya
doaj +3 more sources
ПРЕДПОСЫЛКИ И УСЛОВИЯ ФОРМИРОВАНИЯ МОДЕЛИ«ТРОЙНОЙ СПИРАЛИ» ИННОВАЦИЙ В КАЗАХСТАНЕ
Экономика: стратегия и практика, 2018 The purpose of the paper is to consider the concept of the “triple helix of innovations”, to study the preconditions of it’s formation and to identify the conditions for the implementation of the “triple helix of innovations” model into the innovative ...
F. M. Dnishev, A. S. Gabdulina
doaj
Mergers and Recoil in Triple Massive Black Hole Systems from Illustris
The Astrophysical JournalMassive black hole binaries (MBHBs) form through galaxy mergers and are among the loudest sources of gravitational waves (GWs) in the Universe. If the binary inspiral time is long, a subsequent galaxy merger can introduce a third black hole, forming a ...
Pranav Satheesh +2 more
doaj +1 more source
A Guerra da Tríplice Aliança Aspectos Militares [PDF]
Navigator, 2009 This paper is based in testimonies of high military authorities on the Triple Alliance War. It analyzes several military aspects of this war, such as mobilization, organization, archive registration, infantry, cavalry, artillery, special services ...
Aureliano Pinto de Moura
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source