Results 81 to 90 of about 463,791 (292)

An Eccentric Binary Millisecond Pulsar in the Galactic Plane [PDF]

, 2008
Binary pulsar systems are superb probes of stellar and binary evolution and the physics of extreme environments. In a survey with the Arecibo telescope, we have found PSR J1903+0327, a radio pulsar with a rotational period of 2.15 ms in a highly ...
Arzoumanian, Z., Backer, D. C., Bassa, C., Bhat, N. D. R., Camilo, F., Champion, D. J., Chatterjee, S., Cognard, I., Cordes, J. M., Deneva, J. S., Faucher-Giguere, C. -A., Freire, P. C. C., Gaensler, B. M., Han, J. L., Hessels, J. W. T., Jenet, F. A., Kasian, L., Kaspi, V. M., Kondratiev, V. I., Kramer, M., Lazarus, P., Lazio, J., Lorimer, D. R., McLaughlin, M. A., Nice, D. J., Ransom, S. M., Stairs, I. H., Stappers, B. W., van Leeuwen, J., Venkataraman, A., Vlemmings, W.   +30 more
core   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An iterative deep learning-guided algorithm for directed protein evolution

iScience
Summary: Deep learning has rapidly emerged as a promising toolkit for protein optimization, yet its success remains limited, particularly in the realm of activity.
Xiaofan Li, Qihan Wang, Jianfeng Li, Fangfang Tang, Xiaofeng Yang, Zhanglin Lin   +5 more
doaj   +1 more source

Plate motions recorded in tectonostratigraphic terranes of the Franciscan Complex and evolution of the Mendocino triple junction, northwestern California [PDF]

, 1994
The Mendocino triple junction area of northern California is underlain by the Coastal belt of the Franciscan complex, flanked on the east by the Central and Eastern belts of the Franciscan Complex.
Frederiksen, NO, Harbert, WP, McCulloch, DS, McLaughlin, RJ, Sliter, WV   +4 more
core   +1 more source

On the triple origin of blue stragglers

, 2009
Blue straggler stars (BSSs) are stars observed to be hotter and bluer than other stars with the same luminosity in their environment. As such they appear to be much younger than the rest of the stellar population. Two main channels have been suggested to
Aarseth, Aarseth, Andronov, Binney, Carney, Carney, Ciardullo, D'Angelo, Daniel C. Fabrycky, de La Fuente Marcos, Duquennoy, Eggleton, Eggleton, Eggleton, Fabrycky, Geller, Hagai B. Perets, Heggie, Hills, Iben, Jeon, Kaluzny, Latham, Liu, Mazeh, McCrea, Nelson, O'Brien, Perets, Perets, Pilecki, Preston, Pribulla, Ritter, Rucinski, Sandquist, Sepinsky, Tokovinin, Weldrake, Weldrake   +39 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Dynamical Evolution of Quasi-Hierarchical Triples

We study the gravitational dynamics of quasi-hierarchical triple systems, where the outer orbital period is significantly longer than the inner one, but the outer orbit is extremely eccentric, rendering the time at pericentre comparable to the inner period.
Ginat, Yonadav Barry, Stegmann, Jakob, Samsing, Johan   +2 more
openaire   +2 more sources