Results 61 to 70 of about 79,392 (261)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
An iterative deep learning-guided algorithm for directed protein evolution
iScienceSummary: Deep learning has rapidly emerged as a promising toolkit for protein optimization, yet its success remains limited, particularly in the realm of activity.
Xiaofan Li +5 more
doaj +1 more source
Observational probe into evolution of Compact Hierarchical Triples
, 2023 Compact Hierarchical Triples (CHTs) are systems in which the tertiary star orbits the inner binary in an orbit shorter than 1000 days. These systems were previously thought to be rare but with photometric observations from space telescopes (Kepler and TESS), we have found a few hundred new candidates.
Moharana, Ayush +8 more
openaire +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Mergers and Recoil in Triple Massive Black Hole Systems from Illustris
The Astrophysical JournalMassive black hole binaries (MBHBs) form through galaxy mergers and are among the loudest sources of gravitational waves (GWs) in the Universe. If the binary inspiral time is long, a subsequent galaxy merger can introduce a third black hole, forming a ...
Pranav Satheesh +2 more
doaj +1 more source
A Guerra da Tríplice Aliança Aspectos Militares [PDF]
Navigator, 2009 This paper is based in testimonies of high military authorities on the Triple Alliance War. It analyzes several military aspects of this war, such as mobilization, organization, archive registration, infantry, cavalry, artillery, special services ...
Aureliano Pinto de Moura
doaj
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source