Results 51 to 60 of about 79,392 (261)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Dynamics and evolution of the Azores Triple Junction and its relation to pre-existing major tectonic structures

Communications Earth & Environment
Triple junctions, where three tectonic plates meet, play a critical role in geodynamics. The Azores Triple Junction is critical in the study of triple junctions, challenging traditional models of triple junction stability.
Fernando O. Marques, Attila Balázs, Taras V. Gerya, Anthony Hildenbrand   +3 more
doaj   +1 more source

The influences of the mechanical equilibrium among interfacial tensions at triple junction on the morphological evolution of eutectic lamella

Journal of Materials Research and Technology
In this work, the influence of the mechanical equilibrium among interfacial tensions at three-phase triple junctions on the morphological evolution of growing eutectic lamella was quantitatively investigated through the phase-field simulations.
Zuosheng Li, Sai Tang, Wensheng Liu, Yunzhu Ma   +3 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Hyperspectral Probing of Exciton dynamics and Multiplication in PbSe Nanocrystals

EPJ Web of Conferences, 2013
Height time hyperspectral near IR probing providing broad-band coverage is employed on PbSe nanocrystals, uncovering spectral evolution following high energy photo-excitation due to hot exciton relaxation and recombination.
Bawendi M.G., Strasfeld D., Roitblat A., Sachs H., Gdor I., Ruhman S.   +5 more
doaj   +1 more source

Groomed jet mass as a direct probe of collinear parton dynamics

European Physical Journal C: Particles and Fields, 2020
We study the link between parton dynamics in the collinear limit and the logarithmically enhanced terms of the groomed jet mass distribution, for jets groomed with the modified mass-drop tagger (mMDT).
Daniele Anderle, Mrinal Dasgupta, Basem Kamal El-Menoufi, Marco Guzzi, Jack Helliwell   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The evolution of triple junctions: from failure to success

, 2021
Divergent triple junctions are stable plate margins where three spreading ridges meet. Although it is accepted that this configuration is inherited from an earlier phase of continental rifting, how post-breakup triple junctions emerge from the separation of two plates remains unclear.
Hany Khalil, Fabio Capitanio, Alexander Cruden   +2 more
openaire   +2 more sources