Results 71 to 80 of about 85,786 (301)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
The evolution of triple junctions: from failure to success
, 2021 Divergent triple junctions are stable plate margins where three spreading ridges meet. Although it is accepted that this configuration is inherited from an earlier phase of continental rifting, how post-breakup triple junctions emerge from the separation of two plates remains unclear.
Hany Khalil +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Observational probe into evolution of Compact Hierarchical Triples
, 2023 Compact Hierarchical Triples (CHTs) are systems in which the tertiary star orbits the inner binary in an orbit shorter than 1000 days. These systems were previously thought to be rare but with photometric observations from space telescopes (Kepler and TESS), we have found a few hundred new candidates.
Moharana, Ayush +8 more
openaire +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
The tectonic evolution of the Indian Ocean triple junction, anomaly 6 to present
, 1993 The tectonic evolution of the Indian Ocean ridge-ridge-ridge triple junction is inferred by mapping structures along its traces of the three plates with a long-range side scan sonar.
Mitchell, N. C.; id_orcid, Parson, L. M.
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
An iterative deep learning-guided algorithm for directed protein evolution
iScienceSummary: Deep learning has rapidly emerged as a promising toolkit for protein optimization, yet its success remains limited, particularly in the realm of activity.
Xiaofan Li +5 more
doaj +1 more source
“Triple Bottom Line” as “Sustainable Corporate Performance”: A Proposition for the Future [PDF]
, 2013 Based upon a review of corporate performance, corporate financial performance and corporate social performance, we propose that the concept of ―triple bottom line‖ (TBL) as ―sustainable corporate performance‖ (SCP) should consist of three
Rahman, Azhar Abdul +2 more
core
, 2022 Perovskite oxides are considered to be attractive catalysts for the electrocatalysis of water in an alkaline electrolyte. However, they suffer from low catalytic efficacy and stability that need to be further improved. Here we present a triple perovskite,
Nam Hoon Kim (812590) +3 more
core +1 more source