Results 71 to 80 of about 79,392 (261)

Algorithm of motion on the parameter of rigidity in stability problem on the border of Winklers mediums

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011
To solve the stability problem of one-dimensional elements of construction on the border of different elastic ambiences the algorithm of motion on the parameter of one ambience is suggested.
Evgeniy I Mikhailovskii, Elena V Tulubenskaya   +1 more
doaj   +3 more sources

ПРЕДПОСЫЛКИ И УСЛОВИЯ ФОРМИРОВАНИЯ МОДЕЛИ«ТРОЙНОЙ СПИРАЛИ» ИННОВАЦИЙ В КАЗАХСТАНЕ

Экономика: стратегия и практика, 2018
The purpose of the paper is to consider the concept of the “triple helix of innovations”, to study the preconditions of it’s formation and to identify the conditions for the implementation of the “triple helix of innovations” model into the innovative ...
F. M. Dnishev, A. S. Gabdulina
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Triple System V1371 Tau: An Eclipsing Binary with an Outer Be Star

The Astrophysical Journal
Although triple systems are common, their orbital dynamics and stellar evolution remain poorly understood. We investigated the V1371 Tau system using TESS photometry, multiepoch spectroscopy, and recent interferometric data, confirming it as a rare ...
Danilo F. Rocha, Marcelo Emilio, Jonathan Labadie-Bartz, Coralie Neiner, Julia Bodensteiner, Tomer Shenar, Laerte Andrade, Michael Abdul-Masih, Felipe Navarete, Alessandro Melo, Eduardo Janot-Pacheco, Romualdo Eleutério, Alan W. Pereira   +12 more
doaj   +1 more source

DGLAP evolution extends the triple pole Pomeron fit [PDF]

Physical Review D, 2003
We show that the triple pole pomeron model \cite{CMS} provides an initial condition for a DGLAP evolution \cite{DGLAP} that produces a fit to high $Q^2$ experimental DIS data. We obtain good $χ^2$ for initial scales down to 3 GeV$^2$. Values of the initial scale smaller than 1.45 GeV$^2$ are ruled out at the 90% confidence level.
openaire   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Triple Helix and the evolution of ecosystems of innovation: the case of Silicon Valley

Triple Helix, 2018
Resumen El ecosistema de innovación de Silicon Valley ha evolucionado en la última década. El objectivo de este estudio es el de entender cómo evoluciona ese ecosistema debido a cambios en el papel desempeñado por los agentes de la Triple Hélice, y en ...
Josep M. Pique, Jasmina Berbegal-Mirabent, Henry Etzkowitz   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source