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Evolutionary Conservation Biology: Introduction [PDF]
Evolution has molded the past and paves the future of biodiversity. As anthropogenic damage to the Earth's biota spans unprecedented temporal and spatial scales, it has become urgent to tear down the traditional scientific barriers between conservation ...
Couvet, D., Dieckmann, U., Ferriere, R.
core +1 more source
The Evolutionary Biology of Chelicerata
Chelicerata constitutes an ancient, biodiverse, and ecologically significant group of Arthropoda. The study of chelicerate evolution has undergone a renaissance in the past decade, resulting in major changes to our understanding of the higher-level phylogeny and internal relationships of living orders.
Prashant P, Sharma, Efrat, Gavish-Regev
openaire +2 more sources
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma+9 more
wiley +1 more source
Fewer invited talks by women in evolutionary biology symposia
Lower visibility of female scientists, compared to male scientists, is a potential reason for the under‐representation of women among senior academic ranks.
J. Schroeder+38 more
semanticscholar +1 more source
Evolutionary Biology: Sterile Saviours [PDF]
Sterile sperm castes are widespread, but their significance remains enigmatic. New experiments on Drosophila pseudoobscura reveal that sterile sperm may promote the survival of fertilising sperm inside the spermicidal female reproductive tract.
openaire +4 more sources
Landscape of BRAF transcript variants in human cancer
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda+5 more
wiley +1 more source
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton+17 more
wiley +1 more source