Results 91 to 100 of about 3,031,483 (337)
Evolutionary Multi-Objective Membrane Algorithm
Recent advances in evolutionary algorithms based on membrane computing have shown that the mechanism of membrane computing is an effective way to solve optimization problems. In this work, we propose a new evolutionary multi-objective algorithm that uses
Chuang Liu+3 more
doaj +1 more source
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes+20 more
wiley +1 more source
ECoFFeS: A Software Using Evolutionary Computation for Feature Selection in Drug Discovery
Feature selection is of particular importance in the field of drug discovery. Many methods have been put forward for feature selection during recent decades.
Zhi-Zhong Liu+3 more
doaj +1 more source
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani+14 more
wiley +1 more source
Advent of distributed generation and progression towards an intelligent grid infrastructure within the domain of contemporary electrical power systems have created dynamic load profiles.
Samira Sadeghi+3 more
doaj +1 more source
Fitness Approximation Through Machine Learning with Dynamic Adaptation to the Evolutionary State
We present a novel approach to performing fitness approximation in genetic algorithms (GAs) using machine learning (ML) models, focusing on dynamic adaptation to the evolutionary state.
Itai Tzruia+3 more
doaj +1 more source
IEEE Congress on Evolutionary Computation
• Ant colony optimization • Artificial life • Bioinformatics & bioengineering • Coevolution & collective behavior • Combinatorial & numerical optimization • Constraint & uncertainty handling • Evolutionary data mining • Evolutionary games • Evolutionary ...
semanticscholar +1 more source
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez+17 more
wiley +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma+9 more
wiley +1 more source