Results 91 to 100 of about 258,840 (301)

Review of Reinforcement Learning and Evolutionary Computation Methods for StrategyExploration [PDF]

Jisuanji kexue
Reinforcement learning and evolutionary computation,as two types of nature-inspired learning paradigms,are the mainstream methods for solving strategy exploration problems,and the fusion of these two types of methods provides a general solution for ...
WANG Yao, LUO Junren, ZHOU Yanzhong, GU Xueqiang, ZHANG Wanpeng
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Fitness Approximation Through Machine Learning with Dynamic Adaptation to the Evolutionary State

Information
We present a novel approach to performing fitness approximation in genetic algorithms (GAs) using machine learning (ML) models, focusing on dynamic adaptation to the evolutionary state.
Itai Tzruia, Tomer Halperin, Moshe Sipper, Achiya Elyasaf   +3 more
doaj   +1 more source

Forecasting Recharging Demand to Integrate Electric Vehicle Fleets in Smart Grids [PDF]

, 2019
Electric vehicle fleets and smart grids are two growing technologies. These technologies provided new possibilities to reduce pollution and increase energy efficiency. In this sense, electric vehicles are used as mobile loads in the power grid.
García Caro, Sebastián, García Delgado, Antonio, Guerrero Alonso, Juan Ignacio, León de Mora, Carlos, León de Mora, Carlos (Coordinador), Parejo Matos, Antonio, Personal Vázquez, Enrique   +6 more
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

ECoFFeS: A Software Using Evolutionary Computation for Feature Selection in Drug Discovery

IEEE Access, 2018
Feature selection is of particular importance in the field of drug discovery. Many methods have been put forward for feature selection during recent decades.
Zhi-Zhong Liu, Jia-Wei Huang, Yong Wang, Dong-Sheng Cao   +3 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identification of thermal properties of hardening concrete by means of evolutionary algorithms

Computer Assisted Methods in Engineering and Science, 2017
In this paper, the evolutionary computation procedures for identifying thermophysical properties in hardening massive concrete structures are presented.
Adam Długosz, Iwona Pokorska, Michał A. Glinicki, Roman Jaskulski   +3 more
doaj   +1 more source