Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
A Feature-Based Comparison of Evolutionary Computing Techniques for Constrained Continuous Optimisation [PDF]
arXiv, 2015 Evolutionary algorithms have been frequently applied to constrained continuous optimisation problems. We carry out feature based comparisons of different types of evolutionary algorithms such as evolution strategies, differential evolution and particle swarm optimisation for constrained continuous optimisation.
arxiv
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Evolutionary Diversity Optimization Using Multi-Objective Indicators [PDF]
arXiv, 2018 Evolutionary diversity optimization aims to compute a diverse set of solutions where all solutions meet a given quality criterion. With this paper, we bridge the areas of evolutionary diversity optimization and evolutionary multi-objective optimization.
arxiv
Editorial: Evolutionary computation-based machine learning and its applications for multi-robot systems. [PDF]
Front Neurorobot, 2023 Ma L.
europepmc +1 more source
The roles and applications of extracellular vesicles in cancer
Molecular Oncology, EarlyView.Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley +1 more source
Conservative and non-conservative evolutionary computations in connection with Wolf-Rayet binaries. [PDF]
, 1979 D. Vanbeveren +3 more
openalex +1 more source
Egret Swarm Optimization Algorithm: An Evolutionary Computation Approach for Model Free Optimization. [PDF]
Biomimetics (Basel), 2022 Chen Z +8 more
europepmc +1 more source
, 2016 This book covers the three fundamental topics that form the basis of computational intelligence: neural networks, fuzzy systems, and evolutionary computation.
J. Keller, D. Fogel, Derong Liu
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source