Results 61 to 70 of about 253,604 (271)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Inheritance-Based Diversity Measures for Explicit Convergence Control in Evolutionary Algorithms
, 2018 Diversity is an important factor in evolutionary algorithms to prevent premature convergence towards a single local optimum. In order to maintain diversity throughout the process of evolution, various means exist in literature.
Fortin Félix-Antoine +3 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Evolutionary Computation Methods and their applications in Statistics
Statistica, 2013 A brief discussion of the genesis of evolutionary computation methods, their relationship to artificial intelligence, and the contribution of genetics and Darwin’s theory of natural evolution is provided.
Francesco Battaglia
doaj +1 more source
An Investigation Into the use of Swarm Intelligence for an Evolutionary Algorithm Optimisation; The Optimisation Performance of Differential Evolution Algorithm Coupled with Stochastic Diffusion Search [PDF]
, 2011 The integration of Swarm Intelligence (SI) algorithms and Evolutionary algorithms (EAs) might be one of the future approaches in the Evolutionary Computation (EC).
al-Rifaie, Mohammad Majid +2 more
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Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Evolutionary multiobjective optimization: open research areas and some challenges lying ahead
Complex & Intelligent Systems, 2019 Evolutionary multiobjective optimization has been a research area since the mid-1980s, and has experienced a very significant activity in the last 20 years. However, and in spite of the maturity of this field, there are still several important challenges
Carlos A. Coello Coello +4 more
doaj +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
Jixie chuandong, 2005 The method of rigid-body guidance synthesis of adjustable mechanisms for multiple alternation tasks based on evolutionary computation is proposed.The mechanism optimization model of multi-tasks is established,and the global optimization solution will be ...
杨志刚 +3 more
doaj
RFreak-An R-package for evolutionary computation [PDF]
RFreak is an R package providing a framework for evolutionary computation. By enwrapping the functionality of an evolutionary algorithm kit written in Java, it offers an easy way to do evolutionary computation in R.
Nunkesser, Robin
core