Results 111 to 120 of about 4,260,217 (298)
Epigenetics and Evolutionary Mechanisms
Human Genetics & Embryology, 2013 In this article, an attempt to incorporate recent knowledge of epigenetics into the evolutionary theory is presented. As our interest is to clarify evolutionary mechanisms at the molecular level and to connect them to phenotype evolution, the interplay of drift and selection (near-neutrality) on molecular evolution is briefly reviewed.
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Implementation, elimination of weakly dominated strategies and evolutionary dynamics [PDF]
This paper is concerned with the realism of mechanisms that implement social choice functions in the traditional sense. Will agents actually play the equilibrium assumed by the analysis? As an example, we study the convergence and stability properties of
Giovanni Ponti, Antonio Cabrales
core
Constrained evolutionary wind turbine placement with penalty functions
, 2016 Geographical constraints are essential when planning the locations for wind turbines. In real-world scenarios, especially in densely populated countries, the designated area where turbines can be placed is not an empty map on which the turbines can be ...
Luckehe, D. +5 more
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, 2018 This book is the first in a projected series on Evolutionary Cell Biology, the intent of which is to demonstrate the essential role of cellular mechanisms in transforming the genotype into the phenotype by transforming gene activity into evolutionary ...
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
iScienceSummary: Genomic analyses of bacterial isolates are effective to compare the prevalence of antibiotic resistance genes and virulence determinants in different contexts.
Miquel Sánchez-Osuna +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source