Results 121 to 130 of about 4,260,217 (298)

Recent Evolutionary Algorithm Variants for Combinatorial Optimization Problem

Applications of Modelling and Simulation, 2023
The evolutionary algorithm has been extensively used to solve a range of combinatorial optimization problems. The adaptability of evolutionary algorithm mechanisms provides diverse approaches to handle combinatorial optimization challenges.
Anniza Hamdan, Sze San Nah, Goh Say Leng, Chiew Kang Leng, Tiong Wei King   +4 more
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Regional development: contribution of evolutionary biology [PDF]

This paper tries to set out a potential of application of some evolutionary biology concepts to the issue of regional development. The objective is to show that employment of these concepts or at least inspiration by them may enrich some theories of ...
Lucie Vaskova
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Uncovering the genetic basis of Staphylococcus aureus resistance to single antimicrobial peptides and their combinations

iScience
Summary: Antimicrobial resistance (AMR) poses a critical global health challenge, prompting the exploration of antimicrobial peptides (AMPs) as alternatives.
Bar Maron, Caroline Zanchi, Paul Johnston, Jens Rolff, Jonathan Friedman, Zvi Hayouka   +5 more
doaj   +1 more source

Linking Molecular Mechanisms to their Evolutionary Consequences: a primer

GENETICS
ABSTRACT A major obstacle to predictive understanding of evolution stems from the complexity of biological systems, which prevents detailed characterization of key evolutionary properties. Here, we highlight some of the major sources of complexity that arise when relating molecular mechanisms to their evolutionary consequences and ask ...
Rok Grah, Calin C Guet, Gasper Tkačik, Mato Lagator   +3 more
openaire   +4 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Escape of SARS-CoV-2 Variants KP.1.1, LB.1, and KP.3.3 From Approved Monoclonal Antibodies

Pathogens and Immunity
Background: First-generation anti-SARS-CoV-2 monoclonal antibodies (mAbs) used for prophylaxis or therapeutic purposes in immunocompromised patients have been withdrawn because of the emergence of resistant Omicron variants.
Delphine Planas, Isabelle Staropoli, Cyril Planchais, Emilie Yab, Banujaa Jeyarajah, Yannis Rahou, Matthieu Prot, Florence Guivel-Benhassine, Frederic Lemoine, Vincent Enouf, Etienne Simon-Loriere, Hugo Mouquet, Marie-Anne Rameix-Welti, Olivier Schwartz   +13 more
doaj   +1 more source

Evolutionary mechanisms modulating the mammalian skull development. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Kyomen S, Murillo-Rincón AP, Kaucká M.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source