Results 141 to 150 of about 4,260,217 (298)

Live-bearing cockroach genome reveals convergent evolutionary mechanisms linked to viviparity in insects and beyond. [PDF]

iScience, 2023
Fouks B, Harrison MC, Mikhailova AA, Marchal E, English S, Carruthers M, Jennings EC, Chiamaka EL, Frigard RA, Pippel M, Attardo GM, Benoit JB, Bornberg-Bauer E, Tobe SS.   +13 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Some Notes on Institutions in Evolutionary Economic Geography [PDF]

Within the evolutionary economic geography framework the role of institutions deserves more explicit attention. We argue that territorial institutions are to be viewed as orthogonal to organisational routines in that each territory is characterised by a ...
Koen Frenken, Ron Boschma
core  

Evolutionary mechanisms underlying the diversification of nuclear factor of activated T cells across vertebrates. [PDF]

Sci Rep, 2023
Gamboa M, Kitamura N, Miura K, Noda S, Kaminuma O.   +4 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Learning functional conservation between human and pig to decipher evolutionary mechanisms underlying gene expression and complex traits. [PDF]

Cell Genom, 2023
Li J, Zhao T, Guan D, Pan Z, Bai Z, Teng J, Zhang Z, Zheng Z, Zeng J, Zhou H, Fang L, Cheng H.   +11 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Dancing in the Dark: Evolutionary Psychology and the Problem of Design [PDF]

, 2001
The current Evolutionary Psychology Movement (EPM) argues that the mind/brain cannot be understood except by conceiving of it as the product of design by natural selection.
Griffiths, Paul E., Stotz, Karola
core  

Evaluating the evolutionary mechanisms maintaining alternative mating strategies in a simulated bull trout (Salvelinus confluentus) population. [PDF]

Ecol Evol, 2023
Bernos TA, Chang SL, Giglio RM, Davenport K, Fisher J, Lowery E, Bearlin A, Simmons R, Fortin MJ, Day CC, Landguth EL.   +10 more
europepmc   +1 more source