Results 131 to 140 of about 4,260,217 (298)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Evolutionary pathways in epistatic mechanical networks

Proceedings of the National Academy of Sciences
An elastic spring network is an example of evolvable matter. It can be pruned to couple separated pairs of nodes so that when a strain is applied to one of them, the other responds either in-phase or out-of-phase. This produces two pruned networks, with incompatible functions, that are nearly identical but differ from each other by
Alqatari, Samar, Nagel, Sidney R.
openaire   +2 more sources

Editorial: Evolutionary mechanisms of infectious diseases, volume II. [PDF]

Front Microbiol, 2023
Zhou Z, Gu J, Wang Y.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Comparison of different evolutionary algorithms for global supply chain optimisation and parameter analysis

, 2011
This paper discusses global optimisation from a business perspective in the context of the supply chain operations. A two-silo supply chain was built for experimentation and three approaches were used for global optimisation: a classical evolutionary ...
Sven Schellenberg, Schellenberg, S., Maksud Ibrahimov, Ibrahimov, M., Mohais, A., Zbigniew Michalewicz, Arvind Mohais, Michalewicz, Z.   +7 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Identification of evolutionary mechanisms of myelomatous effusion by single-cell RNA sequencing. [PDF]

Blood Adv, 2023
Sun Z, Ji J, Li Y, Cui Y, Fan L, Li J, Qu X.   +6 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Oropharyngeal resistome remains stable during COVID-19 therapy, while fecal resistome shifts toward a less diverse resistotype

iScience
Summary: Antimicrobial resistance poses a serious threat to global public health. The COVID-19 pandemic underscored the need to monitor the dissemination of antimicrobial resistance genes and understand the mechanisms driving this process. In this study,
Elizaveta V. Starikova, Yulia S. Galeeva, Dmitry E. Fedorov, Elena V. Korneenko, Anna S. Speranskaya, Oksana V. Selezneva, Polina Y. Zoruk, Ksenia M. Klimina, Vladimir A. Veselovsky, Maxim D. Morozov, Daria I. Boldyreva, Evgenii I. Olekhnovich, Alexander I. Manolov, Alexander V. Pavlenko, Ivan E. Kozlov, Oleg O. Yanushevich, Natella I. Krikheli, Oleg V. Levchenko, Dmitry N. Andreev, Filipp S. Sokolov, Aleksey K. Fomenko, Mikhail K. Devkota, Nikolai G. Andreev, Andrey V. Zaborovsky, Sergei V. Tsaregorodtsev, Vladimir V. Evdokimov, Petr A. Bely, Igor V. Maev, Vadim M. Govorun, Elena N. Ilina   +29 more
doaj   +1 more source