Results 71 to 80 of about 4,260,217 (298)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Profiles of low complexity regions in Apicomplexa Genome evolution and evolutionary systems biology [PDF]

, 2016
© 2016 Battistuzzi et al. Background: Low complexity regions (LCRs) are a ubiquitous feature in genomes and yet their evolutionary history and functional roles are unclear.
Schneider, KA, Escalante, AA, Chaudhry, Sophia, Spencer, Matthew K., Escalante|, Battistuzzi, FU, Fisher, D, Battistuzzi, Fabia U., Schneider, Kristan A., Chaudhry, S, Spencer, MK, Fisher, David, Escalante, Ananias   +12 more
core   +1 more source

Evolution of grain trade patterns among RCEP member countries and the potential impacts of agreement signing

Frontiers in Sustainable Food Systems
IntroductionTrade plays a pivotal role in maintaining global grain security. However, the grain trade network (GTN) within Regional Comprehensive Economic Partnership (RCEP) member countries remains unclear.
Minhao Lu, Yingmei Wu, Chao Zhang, Yang Wang, Jiahui Yang, Yi Huang, Yi Wang   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Explicit memory schemes for evolutionary algorithms in dynamic environments [PDF]

, 2007
Copyright @ 2007 Springer-VerlagProblem optimization in dynamic environments has atrracted a growing interest from the evolutionary computation community in reccent years due to its importance in real world optimization problems.
Yang, S, Shengxiang Yang, Yang, Shengxiang   +2 more
core   +1 more source

Path Dependence, Lock-in, and Breakthrough: An Exploration of the Evolutionary Path and Evolutionary Mechanisms of Agricultural Industry Clusters: A Case Study of the Flower and Plant Industry Cluster of Jiangdu District in Yangzhou City, Jiangsu Province

Redai dili
Owing to their low technological relevance and high dependence on policies, agricultural industry clusters are more likely to fall into inefficient locking-ins in the process of evolutionary development.
Xu Jufen, Yang Yahan
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The “Novelty-as-Scarcity” Hypothesis: An Evolutionary Hypothesis to Partially Explain the Global Obesity Epidemic

International Journal for Vitamin and Nutrition Research
The “novelty-as-scarcity” hypothesis proposes that the consumption of novel foods or foods with non-traditional food component ratios, or novel processing methods, are interpreted by the body as fallback foods and produce a false signal of imminent food ...
Miki Ben-Dor, Rainer J. Klement
doaj   +1 more source

Plant grafting: new mechanisms, evolutionary implications

Frontiers in Plant Science, 2014
Grafting, an old plant propagation practice, is still widely used with fruit trees and in recent decades also with vegetables. Taxonomic proximity is a general prerequisite for successful graft-take and long-term survival of the grafted, composite plant.
Eliezer E Goldschmidt
doaj   +1 more source