Results 41 to 50 of about 318,286 (260)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Evolutionary patterns in e‐business strategy [PDF]

International Journal of Operations & Production Management, 2009
PurposeIn 2003 the authors investigated the level of adoption of e‐business by manufacturing firms in Europe. Four company strategies were identified based on different extents of adoption of internet‐based tools for interaction with customers and/or suppliers.
CANIATO, FEDERICO FRANCESCO ANGELO, CAGLIANO, RAFFAELLA, R. GOLINI, M. KALCHSCHMIDT, SPINA, GIANLUCA   +4 more
openaire   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genomic Evolutionary Patterns of Leiomyosarcoma and Liposarcoma [PDF]

Clinical Cancer Research, 2019
Abstract Purpose: Leiomyosarcoma and liposarcoma are common subtypes of soft tissue sarcoma (STS). Patients with metastatic leiomyosarcoma or dedifferentiated liposarcoma (DDLPS) typically have worse outcomes compared with localized leiomyosarcoma or well-differentiated liposarcoma (WDLPS).
Ali Amin-Mansour, Suzanne George, Stefano Sioletic, Scott L. Carter, Mara Rosenberg, Amaro Taylor-Weiner, Chip Stewart, Aaron Chevalier, Sara Seepo, Adam Tracy, Gad Getz, Jason L. Hornick, Marisa R. Nucci, Bradley Quade, George D. Demetri, Chandrajit P. Raut, Levi A. Garraway, Eliezer M. Van Allen, Andrew J. Wagner   +18 more
openaire   +2 more sources

Evolutionary origins for ecological patterns in space [PDF]

Proceedings of the National Academy of Sciences, 2020
Historically, many biologists assumed that evolution and ecology acted independently because evolution occurred over distances too great to influence most ecological patterns. Today, evidence indicates that evolution can operate over a range of spatial scales, including fine spatial scales.
Mark C. Urban, Sharon Y. Strauss, Fanie Pelletier, Eric P. Palkovacs, Mathew A. Leibold, Andrew P. Hendry, Luc De Meester, Stephanie M. Carlson, Amy L. Angert, Sean T. Giery   +9 more
openaire   +4 more sources

Evolutionary patterns of archaea predominant in acidic environment

Environmental Microbiome, 2023
Background Archaea of the order Thermoplasmatales are widely distributed in natural acidic areas and are amongst the most acidophilic prokaryotic organisms known so far.
Rafael Bargiela, Aleksei A. Korzhenkov, Owen A. McIntosh, Stepan V. Toshchakov, Mikhail M. Yakimov, Peter N. Golyshin, Olga V. Golyshina   +6 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Evolutionary genetics: The evolution of plumage patterns [PDF]

Current Biology, 2001
The identification and sequencing of a gene affecting melanin production in the bananaquit, a bird species notable for its polymorphic plumage colour, paves the way for much greater understanding of the evolution of plumage patterns in birds, and the developmental modulations involved in producing new patterns.
Price, Trevor, Bontrager, Alexa
openaire   +2 more sources

Quantitative chemobiology: a guide into the understanding of plant bioactivity

Journal of the Brazilian Chemical Society, 2002
Nothing is more important for human survival today, than understanding nature's mechanisms via a chemo-biological language. This multidisciplinary approach is a complex operation, because it involves integration of several levels of organization, such as
Gottlieb Otto R., Borin Maria Renata de M. B.   +1 more
doaj  

Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence

BMC Evolutionary Biology, 2008
Background Histone methylation can dramatically affect chromatin structure and gene expression and was considered irreversible until recent discoveries of two families of histone demethylases, the KDM1 (previously LSD1) and JmjC domain-containing ...
Zhou Xiaofan, Ma Hong
doaj   +1 more source