Results 101 to 110 of about 3,164,796 (323)

The evolutionary history of 2,658 cancers

Nature, 2017
Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3.
M. Gerstung, Clemency Jolly, I. Leshchiner, S. Dentro, Santiago Gonzalez, T. Mitchell, Yulia Rubanova, Pavana Anur, K. Yu, M. Tarabichi, A. Deshwar, J. Wintersinger, K. Kleinheinz, I. Vázquez-García, K. Haase, L. Jerman, Subhajit Sengupta, G. Macintyre, S. Malikić, Nilgun Donmez, D. Livitz, Marek Cmero, J. Demeulemeester, S. Schumacher, Yu Fan, Xiaotong Yao, Juhee Lee, M. Schlesner, P. Boutros, D. Bowtell, Hongtu Zhu, G. Getz, M. Imieliński, R. Beroukhim, S. C. Sahinalp, Yuan Ji, M. Peifer, F. Markowetz, Ville Mustonen, Ke Yuan, Wenyi Wang, Q. Morris, D. J. Adams, Peter J. Campbell, S. Cao, E. Christie, Yupeng Cun, K. Dawson, Ruben M. Drews, R. Eils, M. Fittall, D. Garsed, G. Ha, H. Lee-Six, I. Martincorena, Layla Oesper, Myron Peto, Benjamin J. Raphael, D. Rosebrock, A. Salcedo, Ruian Shi, S. Shin, O. Spiro, Lincoln Stein, Shankar Vembu, David A. Wheeler, Tsun-Po Yang, P. Spellman, D. Wedge, P. Loo   +69 more
semanticscholar   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Dynamic spectrum access mechanism based on graphical evolutionary game in radio networks

Tongxin xuebao, 2015
In order to realize efficient data transmission for users in radio networks,a dynamic spectrum access mechanism based on graphical evolutionary game was proposed for the bounded rationality characteristic of users,while graphical game can better reflect ...
Fang-wei LI, Ying-hui YUAN, Jiang ZHU
doaj   +2 more sources

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce, Goknur Selen Kocak, José Verdú‐Díaz, Jorge Alonso‐Pérez, Kristl G. Claeys, Tanya Stojkovic, Gorka Fernández‐Eulate, Pascal Laforêt, Najoua Miladi, Filipe Di Pace, Cristiane Araujo Martins Moreno, Edmar Zanoteli, Conrad C. Weihl, Volker Straub, Ana Töpf, Jordi Díaz‐Manera, Sarcoglycan European Cohort Consortium, Adele D′Amico, Adolfo López de Munain, Alicia Alonso‐Jiménez, Ana Camacho‐Salas, Andrea Gangfuß, Andrés Nascimento, Anna Sarkozy, Anneke J. van der Kooi, Arturo Fraga‐Bau, Béla Melegh, Benedikt Schoser, Bjarne Udd, Blaz Koritnik, Carlos Ortez, Chiara Marini Bettolo, Chiara Panicucci, Claudia Weiss, Claudio Bruno, Claudio Semplicini, Cristina Dominguez‐González, Cristina Garrido, David Gómez‐Andrés, Edoardo Malfatti, Elena Pegoraro, Elke De Vos, Francina Munell, Gabriele Dekomien, Giacomo Pietro Comi, Giorgio Tasca, Isabelle Richard, Jan L. De Bleecker, Jana Haberlová, Jesper Helbo Storgaard, Johanna Palmio, John Vissing, Juan Carlos de Leon‐Hernández, Kinga Hadzsiev, Laura Costa‐Comellas, Lea Leonardis, Leroy ten Dam, Lidia González‐Quereda, Luca Bello, Luisa Politano, Manuela Santos, Marianne de Visser, Marie Rohlenová, Matteo Garibaldi, Michela Guglieri, Nicolas Deconinck, Nicoline Løkken, Omar Abdel‐Mannan, Pia Gallano, Roberto Fernández‐Torrón, Ulrike Schara‐Schmidt, Vincenzo Nigro, Vittoria Zangaro   +72 more
wiley   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Improving prediction performance of stellar parameters using functional models

, 2015
This paper investigates the problem of prediction of stellar parameters, based on the star's electromagnetic spectrum. The knowledge of these parameters permits to infer on the evolutionary state of the star. From a statistical point of view, the spectra
Curé, Michel, Robbiano, Sylvain, Saumard, Matthieu   +2 more
core   +1 more source

Evolution of intrinsic disorder in the structural domains of viral and cellular proteomes

Scientific Reports
Intrinsically disordered regions are flexible regions that complement the typical structured regions of proteins. Little is known however about their evolution.
Fizza Mughal, Gustavo Caetano-Anollés
doaj   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

β-Glucan in invertebrates

Invertebrate Survival Journal, 2004
b-Glucans, as biologically active polysaccharides, have been used for decades but only recently have become a focus of evolutionary studies. As b-glucans are shown to be active in all animal species studied - from earthworms to humans - we can safely ...
V Vetvicka, P Sima
doaj  

Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis.

PLoS ONE, 2009
BackgroundMicroRNAs (miRNAs) are small, endogenously expressed non-coding RNAs that regulate mRNAs post-transcriptionally. Previous studies have explored miRNA evolutionary trend, but evolutionary history and pattern in the miRNA world are still not ...
Li Guo, Beili Sun, Fei Sang, Wei Wang, Zuhong Lu   +4 more
doaj   +1 more source