Results 41 to 50 of about 192,884 (311)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Evolutionary Optimization Techniques on Computational Grids [PDF]
, 2002 Optimization of complex objective functions such as environmental models is a compute-intensive task, difficult to achieve by classical optimization techniques. Evolutionary techniques such as genetic algorithms present themselves as the best alternative to solving this problem.
Baker Abdalhaq +3 more
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Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
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FoundationsIn recent years, large-scale optimization problems have become increasingly common in various fields, such as machine learning and data analysis, generating increased references to both computational cost and accurate solutions.
Glykeria Kyrou +3 more
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Acta Polytechnica CTU Proceedings, 2017 The article focuses on analysis of possibilities of operatic control of railway traffic and its automatization and its support by information systems. Conditions, necessary pieces of input information like infrastructure description are discussed. RailML
Dušan Kamenický +3 more
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Heuristic methods for evolutionary computation techniques [PDF]
Journal of Heuristics, 1996 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Exploring adaptation with evolutionary activity plots
, 2006 Evolutionary activity statistics and their visualization are introduced, and their motivation is explained. Examples of their use are described, and their strengths and limitations are discussed.
Bullock, Seth, Bedau, Mark
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The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Using Optimization Techniques in Grammatical Evolution
Future InternetThe Grammatical Evolution technique has been successfully applied to a wide range of problems in various scientific fields. However, in many cases, techniques that make use of Grammatical Evolution become trapped in local minima of the objective problem ...
Ioannis G. Tsoulos +2 more
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Gravitation search algorithm: Application to the optimal IIR filter design
Journal of King Saud University: Engineering Sciences, 2014 This paper presents a global heuristic search optimization technique known as Gravitation Search Algorithm (GSA) for the design of 8th order Infinite Impulse Response (IIR), low pass (LP), high pass (HP), band pass (BP) and band stop (BS) filters ...
Suman Kumar Saha +3 more
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