Results 61 to 70 of about 192,884 (311)

Visual Analysis Scenarios for Understanding Evolutionary Computational Techniques’ Behavior

Information, 2019
Machine learning algorithms are used in many applications nowadays. Sometimes, we need to describe how the decision models created output, and this may not be an easy task.
Aruanda Meiguins, Yuri Santos, Diego Santos, Bianchi Meiguins, Jefferson Morais   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Application of Multiobjective Evolutionary Techniques for Robust Portfolio Optimization

International Journal of Interactive Multimedia and Artificial Intelligence, 2013
On December 20 of 2012 Sandra García Rodríguez defended his PhD at Carlos III of Madrid (Spain), called: “Application of Multiobjective Techniques for Robust Portfolio Optimization”. This thesis was supervised by Dr. David Quintana Montero and Dr. Inés M.
Sandra Garcia Rodriguez
doaj   +1 more source

A study of the effects of clustering and local search on radio network design: evolutionary computation approaches [PDF]

, 2008
Eighth International Conference on Hybrid Intelligent Systems. Barcelona, 10-12 September 2008The goal of this paper is twofold. First, we want to make a study about how evolutionary computation techniques can efficiently solve the radio network design ...
Sáez, Yago, Yago Saez, Pedro Isasi, Sáez Achaerandio, Yago, Zazo, Fernando, Fernando Zazo, Isasi, Pedro, Isasi Viñuela, Pedro   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Evolutionary Computation: Theories, Techniques, and Applications

Applied Sciences
Evolutionary computation is now nearly 50 years old, originating with the seminal work of John Holland at the University of Michigan in 1975 which introduced the genetic algorithm [...]
Vincent A. Cicirello
doaj   +1 more source

La evolución de técnicas y fenómenos: hacia una explicación de la "confección" del mundo

Crítica, 2019
In recent articles some authors (e.g. Pickering 1989, Hacking 1992) have pointed out a process of gradual adjustment or tailoring between phenomena, models and experimental techniques.
Sergio F. Martínez, Edna Suárez
doaj   +1 more source