Results 61 to 70 of about 165,885 (265)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Investigation on Evolutionary Computation Techniques of a Nonlinear System
Modelling and Simulation in Engineering, 2011 The main aim of this work is to show that such a powerful optimizing tool like evolutionary algorithms (EAs) can be in reality used for the simulation and optimization of a nonlinear system.
Tran Trong Dao
doaj +1 more source
New Molecular Genetic Techniques for the Inference of Evolutionary Relationships
Acta Biologica Slovenica, 1991 Molecular genetic techniques have advanced greatly in the last few years, and provided powerful tools for phylogenetic research. The two most important methods for characterising nucleic acids are restriction-enzyme fragment analysis, and nucleotide ...
Adam Marchant
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Evolutionary Techniques for Reverse Auctions
Intelligent Control and Automation, 2013 Winner determination is one of the main challenges in combinatorial auctions. However, not much work has been done to solve this problem in the case of reverse auctions using evolutionary techniques. This has motivated us to propose an improvement of a genetic algorithm based method, we have previously proposed, to address two important issues in the ...
Shubhashis Kumar Shil +2 more
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Evolutionary Computation and Its Applications in Neural and Fuzzy Systems
Applied Computational Intelligence and Soft Computing, 2011 Neural networks and fuzzy systems are two soft-computing paradigms for system modelling. Adapting a neural or fuzzy system requires to solve two optimization problems: structural optimization and parametric optimization.
Biaobiao Zhang +3 more
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Electricity Peak Load Forecasting using CGP based Neuro Evolutionary Techniques
International Journal of Computational Intelligence Systems, 2016 Proficient Economic and Financial planning is critical to the successful and efficient operation of power generating and distributing units. This planning becomes quite facile if the accurate and precise knowledge regarding the required power load is ...
Gul Muhammad Khan, Rabia Arshad
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Comparison of Evolutionary Techniques for Value-at-Risk Calculation
, 2007 The Value-at-Risk (VaR)approach has been used for measuring and controlling the market risks in financial institutions. Studies show that the t-distribution is more suited to representing the financial asset returns in VaR calculations than the commonly used normal distribution.
Gonul Uludag +3 more
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source