Results 81 to 90 of about 6,029,102 (240)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

An adaptive data structure for evolutionary multi-objective algorithms with unbounded archives

, 2012
Archives have been widely used in evolutionary multi-objective optimization in order to store the optimal points found so far during the optimization process. Usually the size of an archive is bounded which means that the number of points it can store is
Yuen, J., Joseph Yuen, Gao, S., Markus Wagner, Sophia Gao, Wagner, M., Neumann, F., Frank Neumann   +7 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

A Review of Gait Optimization Based on Evolutionary Computation

Applied Computational Intelligence and Soft Computing, 2010
Gait generation is very important as it directly affects the quality of locomotion of legged robots. As this is an optimization problem with constraints, it readily lends itself to Evolutionary Computation methods and solutions.
Daoxiong Gong, Jie Yan, Guoyu Zuo
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Estimating the reproductive potential of offspring in evolutionary heuristics for combinatorial optimization problems

, 2011
This paper proposes a metaheuristic selection technique for controlling the progress of an evolutionary algorithm (and possibly other heuristic search techniques) to manipulate and make use of the relationship between runtime and solution quality.
Tuson, A., Parkinson, E., Eddy Parkinson, Andrew Tuson, Zbigniew Michalewicz, Ghandar, A., Michalewicz, Z., Adam Ghandar   +7 more
core   +1 more source

On the Use of Colour-Based Segmentation in Evolutionary Image Composition [PDF]

, 2018
Part of the IEEE World Congress on Computational Intelliegence (IEEE WCCI 2018). Which includes conferences IJCNN 2018, IEEE CEC 2018 and FUZZ-IEEE 2018.Evolutionary algorithms have been widely used in the area of creativity in order to help create art ...
Neumann, A., Aneta Neumann, Frank Neumann, Neumann, F.   +3 more
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Exploring Evolutionary Economic Geographies [PDF]

Evolutionary approaches in economics have gathered increasing support over the last 25 years. Despite an impressive body of literature, economists are still far from formulating a coherent research paradigm.
David L. Rigby, Jürgen Essletzbichler
core