Results 51 to 60 of about 6,029,102 (240)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Grey-box model identification via evolutionary computing [PDF]
, 2002 This paper presents an evolutionary grey-box model identification methodology that makes the best use of a priori knowledge on a clear-box model with a global structural representation of the physical system under study, whilst incorporating accurate ...
Y. Li, Li, Y., K.C. Tan, Tan, K.C.
core +1 more source
Applying Bounding Techniques on Grammatical Evolution
ComputersThe Grammatical Evolution technique has been successfully applied to some datasets from various scientific fields. However, in Grammatical Evolution, the chromosomes can be initialized at wide value intervals, which can lead to a decrease in the ...
Ioannis G. Tsoulos +2 more
doaj +1 more source
Cognitive rhythms and evolutionary algorithms in university timetables scheduling
Revista de Matemática: Teoría y Aplicaciones, 2015 The main purpose of this research is to design a methodology based on evolutionary algorithms to university timetable scheduling. This methodology will consider the students’ cognitive rhythms, which establish that teaching certain subjects in specific ...
Omar Danilo Castrillón
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Introducing a Parallel Genetic Algorithm for Global Optimization Problems
AppliedMathThe topic of efficiently finding the global minimum of multidimensional functions is widely applicable to numerous problems in the modern world. Many algorithms have been proposed to address these problems, among which genetic algorithms and their ...
Vasileios Charilogis, Ioannis G. Tsoulos
doaj +1 more source
Performance Comparison Of Evolutionary Algorithms For Image Clustering [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2014 Evolutionary computation tools are able to process real valued numerical sets in order to extract suboptimal solution of designed problem. Data clustering algorithms have been intensively used for image segmentation in remote sensing applications ...
P. Civicioglu +5 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Visual Analysis Scenarios for Understanding Evolutionary Computational Techniques’ Behavior
Information, 2019 Machine learning algorithms are used in many applications nowadays. Sometimes, we need to describe how the decision models created output, and this may not be an easy task.
Aruanda Meiguins +4 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source