Results 51 to 60 of about 863,024 (318)

Theory of the evolutionary minority game

, 2000
We present a theory which describes a recently introduced model of an evolving, adaptive system in which agents compete to be in the minority. The agents themselves are able to evolve their strategies over time in an attempt to improve their performance.
Hui, P. M., Johnson, N. F., Lo, T. S.
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Information Geometry and Evolutionary Game Theory [PDF]

, 2009
The Shahshahani geometry of evolutionary game theory is realized as the information geometry of the simplex, deriving from the Fisher information metric of the manifold of categorical probability distributions.
Harper, Marc
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Promotion of cooperation by selective group extinction

New Journal of Physics, 2016
Multilevel selection is an important organizing principle that crucially underlies evolutionary processes from the emergence of cells to eusociality and the economics of nations.
Marvin A Böttcher, Jan Nagler
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Evolutionary Theory and Computerised Genetic Algorithms [PDF]

, 2018
Neo-Darwinism can be usefully studied with the help of a Computerised Genetic Algorithm. Only a mathematical approach can reveal the shortcomings of the current dogma and point the way to a revised definition of the theory of ...
Hough, Derek Philip
core  

Evolutionary connectionism: algorithmic principles underlying the evolution of biological organisation in evo-devo, evo-eco and evolutionary transitions [PDF]

, 2015
The mechanisms of variation, selection and inheritance, on which evolution by natural selection depends, are not fixed over evolutionary time. Current evolutionary biology is increasingly focussed on understanding how the evolution of developmental ...
A Clark, A Crombach, A Davies, A Mesoudi, A Traulsen, A Wagner, A Wagner, Adam Davies, Adam Jackson, AF Bourke, AG Jones, B Gallardo, B Matthews, BE Beisner, C Folke, C. L. Buckley, CA Solari, Chris Cox, CP Doncaster, CR Shalizi, CS Holling, D Schluter, D Simberloff, Daniel Power, DC Queller, DE Rumelhart, DH Ackley, DJ Earl, DM Post, DO Hebb, DS Wilson, DS Wilson, DS Wilson, E Chastain, E Jablonka, E Jablonka, E Jablonka, E Szathmáry, E Szathmáry, EG Leigh, FC Poderoso, FC Santos, FM Bator, G Bateson, G O’Toole, G Ritzer, GB Müller, GC Gallopín, GE Hinton, GE Hinton, GE Hinton, GP Wagner, GP Wagner, GP Wagner, GP Wagner, H Lipson, HE Hoekstra, J Clune, J Draghi, J Gerhart, J Maynard Smith, J Maynard Smith, J Maynard Smith, J Maynard Smith, J Odling-Smee, J Odling-Smee, JD Farmer, JF Fontanari, JH Lawton, JJ Hopfield, JJ Hopfield, JJ Hopfield, JL Hendrikse, JM Montoya, JM Pacheco, JN Thompson, JP Wright, JR Snowdon, K Jax, K Laland, K Sigmund, KN Laland, KN Laland, KN Laland, Kostas Kouvaris, L Margulis, L Margulis, L Margulis, L Partridge, L Valiant, Loizos Kounios, LW Buss, M Blute, M Chicurel, M Gell-Mann, M Hauschild, M Kallich, M Kirchner, M Parter, M Pavlicev, M Pelikan, M Pigliucci, M Pigliucci, M Pigliucci, M Toussaint, M Trestman, MA Nowak, MJ West-Eberhard, ML Johnson, MO Jackson, MO Jackson, N Kashtan, N Kashtan, P Godfrey-Smith, PD Sniegowski, PM Brakefield, R Amundson, R Cropp, R Levins, R Mills, R Riedl, RA Watson, RA Watson, RA Watson, RA Watson, RA Watson, RA Watson, RC Lewontin, RC O’Reilly, RE Michod, RE Michod, RE Michod, RE Michod, Richard A. Watson, Rob Mills, S Huang, S Okasha, S Okasha, S Segbroeck Van, SA Frank, SA Frank, SA Frank, SA Levin, SA Levin, SB Carroll, Simon T. Powers, Simon Tudge, SJ Arnold, ST Powers, T Dayan, T Mitchell, TM Lenton, TM Lenton, TW Schoener, W Ghang, WL Brown, WR Ashby   +156 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source