Results 51 to 60 of about 6,349,669 (299)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A resource-based game theoretical approach for the paradox of the plankton [PDF]
PeerJ, 2016 The maintenance of species diversity is a central focus in ecology. It is not rare to observe more species than the number of limiting resources, especially in plankton communities.
Weini Huang +3 more
doaj +2 more sources
04081 Abstracts Collection – Theory of Evolutionary Algorithms [PDF]
, 2006 From 15.02.04 to 20.02.04, the Dagstuhl Seminar 04081 ``Theory of Evolutionary Algorithms'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl.
Vose, Michael D. +3 more
core +1 more source
Kant’s Moral Theory Meets Evolutionary Theory [PDF]
Journal of Philosophical InvestigationsThis paper delves into the intersection between Kant’s moral theory and evolutionary perspectives on personhood. It explores how Kant’s emphasis on rationality in moral agency aligns with evolutionary studies on the development of moral behaviors.
Alireza Mansouri
doaj +1 more source
Evolutionary Game Theory: A Renaissance [PDF]
Games, 2017 Economic agents are not always rational or farsighted and can make decisions according to simple behavioral rules that vary according to situation and can be studied using the tools of evolutionary game theory. Furthermore, such behavioral rules are themselves subject to evolutionary forces. Paying particular attention to the work of young researchers,
openaire +5 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
06061 Abstracts Collection – Theory of Evolutionary Algorithms [PDF]
, 2006 From 05.02.06 to 10.02.06, the Dagstuhl Seminar 06061 ``Theory of Evolutionary Algorithms'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl.
Arnold, Dirk V. +3 more
core +1 more source
Promotion of cooperation by selective group extinction
New Journal of Physics, 2016 Multilevel selection is an important organizing principle that crucially underlies evolutionary processes from the emergence of cells to eusociality and the economics of nations.
Marvin A Böttcher, Jan Nagler
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source