Results 91 to 100 of about 888,235 (335)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Zygon, 1987 . As the crusade to outlaw the teaching of evolution changed to a battle for equal time for creationism, the ideological defenses of that doctrine also shifted from primarily biblical to more scientific grounds.
doaj +2 more sources
Cahiers Jean Moulin, 2017 In Italy, as in other European countries at the end of the 19th century, the biological theory of evolution and the social darwinism played an important role in the scientific controversies.
Dario Di Cecca
doaj +1 more source
The Potential for Rapid Evolution under Anthropogenic Climate Change [PDF]
, 2019 Renee A. Catullo +3 more
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Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Arts et Savoirs, 2018 This paper first examines the opinions of the naturalist Ernst Haeckel (1834-1919) about poetry and myths, parted between rejection and acknowledgment. Then, it presents the rhetorics of Haeckel himself when arguing his own scientific theories.
Nicolas Wanlin
doaj +1 more source
Lithospheric Mantle Evolution beneath the Eifel (Germany): Constraints from Sr-Nd-Pb Isotopes and Trace Element Abundances in Spinel Peridotite and Pyroxenite Xenoliths [PDF]
, 2003 G. Witt-Eickschen
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source