Results 101 to 110 of about 2,971 (281)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
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Epigênese e epigenética: as muitas vidas do vitalismo ocidental
Horizontes AntropológicosResumo A análise da história e dos usos contemporâneos dos termos epigênese, atribuído a Aristóteles, e epigenética, criado no século XX pelo biólogo C. H.
Gláucia Silva +1 more
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
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Knowledge management and history [PDF]
Capitalisation of the history of a technology, a technique or a concept within an industrial company is relevant to historians. However it largely exceeds the historical problems from a Knowledge Management point of view.
Bertrand Pauget +3 more
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
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The workings of a Darwinist brain: Guedes Cabral and the evolutionism of Funções do cérebro (1876)
, 2013 Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Rio de Janeiro, RJ, BrasilO livro Funções do cérebro, do médico Domingos Guedes Cabral, é reconhecido como um dos primeiros trabalhos ...
Waizbort, Ricardo Francisco +1 more
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Dados: Revista de Ciências Sociais, 1999 In an examination of Hayek?s social philosophy, the article seeks to distinguish between socio-epistemological arguments, which postulate the radical ignorance of social actors, and the conservative political conclusions usually associated with Hayek?s ...
Kerstenetzky Celia Lessa
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