Results 91 to 100 of about 2,971 (281)
International conference on evolutionism and rationalism Book of abstracts
, 1997 Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid.
Puertas, Jesus (eds.) +3 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
José Veríssimo: pensamento social e etnografia da Amazônia (1877/1915)
Dados: Revista de Ciências Sociais, 1999 This essay offers a preliminary outline of the main aspects of Pará intellectual José Veríssimo?s theses in the field of ethnography and social thought as addressed to the Amazon society in the latter decades of the nineteenth century and first fifteen ...
Bezerra Neto José Maia
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Markets and New Industrial Policy:Systemic Directionality or Polycentric Evolutionism [PDF]
Proponents of “new industrial policy” claim that systemic directionality can be imparted to market economies in ways recognising the epistemic challenges of complexity and uncertainty.
Cheang, Bryan, Pennington, Mark
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Evolutionism as a Methodological Principle for Development of Science
, 2007 Обґрунтовується застосування еволюціонізму як методологічного принципу розвитку науки. Оскільки наука має неймовірну здатність встановлювати тісний зв’язок між причиною і наслідком, еволюціонізм, застосований як методологічний принцип, не тільки ...
Русяєва, Т.Г.
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
, 2004 Missionaries, evolutionism and pacific anthropology: the correspondence of Lorimer Fison and Robert ...
Helen Gardner (13072758)
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