Results 41 to 50 of about 10,925 (230)

Discovery and Validation of a Compound to Target Ewing’s Sarcoma

Pharmaceutics, 2021
Ewing’s sarcoma, characterized by pathognomonic t (11; 22) (q24; q12) and related chromosomal ETS family translocations, is a rare aggressive cancer of bone and soft tissue.
Ellie Esfandiari Nazzaro, Fahad Y. Sabei, Walter K. Vogel, Mohamad Nazari, Katelyn S. Nicholson, Philip R. Gafken, Olena Taratula, Oleh Taratula, Monika A. Davare, Mark Leid   +9 more
doaj   +1 more source

Silent Malignant Occipital Swelling

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2018
Ewing's sarcoma commonly reported in long bones and pelvis. Primary Ewing's sarcoma of the cranium is rare. They behave differently from their counterpart involving the long bones. They usually respond well to chemotherapy and radiotherapy.
Sumeet V Sasane, Sushanta K Sahoo, Chhitij Srivastava, Ajay Singh, Bal Krishna Ojha   +4 more
doaj   +1 more source

Identification of Common Oncogenic Genes and Pathways Both in Osteosarcoma and Ewing’s Sarcoma Using Bioinformatics Analysis

Journal of Immunology Research, 2022
This study was aimed at exploring common oncogenic genes and pathways both in osteosarcoma and Ewing’s sarcoma. Microarray data were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using the
Jingwei Zhang, Junchao Huang, Wenjun Liu, Liang Ding, Dongdong Cheng, Haijun Xiao   +5 more
doaj   +1 more source

Peripheral primitive neuroendocrine tumor of the chest wall—A case report with pathological correlation

Radiology Case Reports, 2018
Primitive neuroectodermal tumor is a high-grade malignant tumor originating from the neural crest and neuroectoderm, which can be subdivided into central and peripheral categories.
Jidi Gao, MD, Erika Chow, BA, Aishatu Aloma, MD, Payal Gupta, MD   +3 more
doaj   +1 more source

Primary Ewing’s Sarcoma of the Spine: About a Case

Global Pediatric Health, 2022
Ewing’s sarcoma is a primary malignant bone tumor affecting individuals in the second decade of life. Primary sarcomas of the spine are rare and the occurrence of primary Ewing’s sarcoma in the spine is very rare.
Amine Cherraqi MD, Abir Lemrabet MD, Ibrahima Diallo Dokal MD, Najlae Lrhorfi MD, Hicham Belghiti MD, Nazik Allali PhD, Latifa Chat PhD   +6 more
doaj   +1 more source

Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. [PDF]

, 2017
Methionine dependence is due to the overuse of methionine for aberrant transmethylation reactions in cancer. Methionine dependence may be the only general metabolic defect in cancer.
Bouvet, Michael, Chishima, Takashi, DeLong, Jonathan C, Dry, Sarah M, Eilber, Fritz C, Endo, Itaru, Han, Qinghong, Hiroshima, Yukihiko, Hoffman, Robert M, Hwang, Ho Kyoung, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Shukuan, Li, Yunfeng, Lwin, Thinzar M, Miyake, Kentaro, Murakami, Takashi, Nelson, Scott D, Singh, Arun S, Tan, Yuying, Tanaka, Kuniya   +21 more
core  

Intensity modulated radiotherapy (IMRT) in the treatment of children and Adolescents - a single institution's experience and a review of the literature [PDF]

, 2009
Background While IMRT is widely used in treating complex oncological cases in adults, it is not commonly used in pediatric radiation oncology for a variety of reasons. This report evaluates our 9 year experience using stereotactic-guided, inverse planned
Florian Sterzing, Eva M Stoiber, Simeon Nill, Harald Bauer, Peter Huber, Jürgen Debus, Marc W Münter, Intensity Modulated Radiation Therapy Collaborative Working Group, A Eisbruch, C Nutting, A Pirzkall, W Zhen, MW Munter, D Schulz-Ertner, MW Munter, SL Wolden, G Studer, ML Cavey, M Guckenberger, L Veldeman, F Sterzing, A Boyer, TR Mackie, EJ Hall, EJ Hall, SF Kry, U Schneider, M Mazonakis, B Rhein, A Bhatnagar, JA Penagaricano, AC Paulino, BS Teh, JA Penagaricano, E Huang, N Jain, MJ Krasin, TM Schroeder, MW McDonald, AE Curtis, SE Combs, S Laskar, RB Kuppersmith, M Fuss, D Verellen, M Koshy, JS Welsh, EJ Hall, J Blatt, DG Gold, AC Paulino, HM Lin, LL Robison, GT Armstrong, F Nguyen, W Dorr, W Parker, A Rembielak   +57 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Ewing’s Sarcoma of the Breast in a Young Woman: A Case Report and Review of the Literature

Frontiers in Oncology, 2022
Ewing’s Sarcoma Family Tumors (ESFT) include classic Ewing’s sarcoma of bone, extra-skeletal Ewing’s sarcoma (EES), malignant small cell tumor of the chest wall (Askin tumor), and soft tissue-based Peripheral Primitive Neuroectodermal tumors (pPNET). The
Simona Papi, Francesca Combi, Francesca Combi, Silvia Segattini, Silvia Accogli, Enza Palma, Anna Gambini, Alessia Andreotti, Gabriele Luppi, Giovanni Tazzioli   +9 more
doaj   +1 more source

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

Advanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou, Peilong Lai, Guanjie Peng, Bo Lu, Lizhen Jiang, Xinyue Li, Jinghong Chen, Ladi Mo, Qiong Mao, Haichuan Zhang, Jinxin Fang, Yi Meng, Aochu Liu, Yingyin Gao, Andong Huang, Wenhui Lin, Shiwen Hu, Zerong Guan, Xiaolan Ye, Zhenguo Liu, Liling Jiang, Yueyuan Zheng, Xianping Shi   +22 more
wiley   +1 more source