Results 31 to 40 of about 7,060 (163)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Gene expression response to EWS–FLI1 in mouse embryonic cartilage

Genomics Data, 2014
Ewing's sarcoma is a rare bone tumor that affects children and adolescents. We have recently succeeded to induce Ewing's sarcoma-like small round cell tumor in mice by expression of EWS–ETS fusion genes in murine embryonic osteochondrogenic progenitors ...
Miwa Tanaka, Ken-ichi Aisaki, Satoshi Kitajima, Katsuhide Igarashi, Jun Kanno, Takuro Nakamura   +5 more
doaj   +1 more source

Extra-skeletal Ewing’s sarcoma of the leg with multiple skeletal and pulmonary metastases: A rare pediatric case report

SAGE Open Medical Case Reports, 2023
Being the second most common malignant bone tumor in children and young adults, Ewing’s sarcoma can also occur as a primary soft-tissue tumor called extraosseous or extra-skeletal Ewing’s sarcoma.
Yahya El Harras, Safaa Choayb, Khadija Laasri, Nazik Allali, Latifa Chat, Siham El Haddad   +5 more
doaj   +1 more source

Copine‐4 Paraneoplastic Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We characterize copine‐4 (CPNE4)‐IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse‐brain indirect immunofluorescence assay over 2 years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum‐restricted synaptic pattern.
Mimi S. Fang, Amy Ml Quek, Clement Yong, Amir Adeli, Gabrielle N. Conway, Connie E. Lesnick, Diana Anissian, Divyanshu Dubey, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael Gilligan, Andrew McKeon   +12 more
wiley   +1 more source

Primary mediastinal Ewing’s sarcoma presenting with sudden and severe chest pain: a case report

Frontiers in Oncology
Ewing’s sarcoma, characterized by small round cell morphology, is a rare malignancy, with mediastinal Ewing’s sarcoma being even less common. This case describes a distinctive presentation of primary mediastinal Ewing’s sarcoma in a 32-year-old male ...
Chen Su, Chen Su, Xiaobo Zhu, Xiaobo Zhu, Junjie Zhang, Junjie Zhang   +5 more
doaj   +1 more source

Latest developments in the pathobiology of Ewing sarcoma

Journal of Bone Oncology, 2022
Ewing's sarcoma (ES) is an aggressive malignant tumor commonly affecting adolescents. The standard of care includes surgical treatment and systemic therapies, although ES patients often develop drug resistance, leading to disease progression ...
Irina Karlina, Brett A. Schroeder, Kirill Kirgizov, Olga Romantsova, Andrey L. Istranov, Andrey Nedorubov, Peter Timashev, Ilya Ulasov   +7 more
doaj   +1 more source

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

Primitive Neuroectodermal Tumor of the Cervix Uteri

International Journal of Hematology-Oncology and Stem Cell Research, 2012
Ewing’s sarcoma is a round cell malignancy of bone and soft tissue that occurs predominately in adolescents and young adults.It is an uncommon malignancy, but is recognized as the second most prevalent primary bone tumor worldwide.
Zineb Benbrahim, Christine Haie-Meder, Pierre Duvillard, Omar El Mesbahi, Axel Le Cesne, Patricia Pautier   +5 more
doaj  

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Primitive Neuroectodermal Tumor of the Cervix Uteri: A case report and review of literature

International Journal of Hematology-Oncology and Stem Cell Research, 2015
Ewing’s sarcoma is a round cell malignancy of bone and soft tissue that occurs predominately in adolescents and young adults.It is an uncommon malignancy, but is recognized as the second most prevalent primary bone tumor worldwide.
Zineb Benbrahim, Christine Haie-Meder, Pierre Duvillard, Omar El-Mesbahi, Axel Le-Cesne, Patricia Pautier   +5 more
doaj