Results 41 to 50 of about 8,039 (180)

Identification of Common Oncogenic Genes and Pathways Both in Osteosarcoma and Ewing’s Sarcoma Using Bioinformatics Analysis

Journal of Immunology Research, 2022
This study was aimed at exploring common oncogenic genes and pathways both in osteosarcoma and Ewing’s sarcoma. Microarray data were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using the
Jingwei Zhang, Junchao Huang, Wenjun Liu, Liang Ding, Dongdong Cheng, Haijun Xiao   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Peripheral primitive neuroendocrine tumor of the chest wall—A case report with pathological correlation

Radiology Case Reports, 2018
Primitive neuroectodermal tumor is a high-grade malignant tumor originating from the neural crest and neuroectoderm, which can be subdivided into central and peripheral categories.
Jidi Gao, MD, Erika Chow, BA, Aishatu Aloma, MD, Payal Gupta, MD   +3 more
doaj   +1 more source

Primary Ewing’s Sarcoma of the Spine: About a Case

Global Pediatric Health, 2022
Ewing’s sarcoma is a primary malignant bone tumor affecting individuals in the second decade of life. Primary sarcomas of the spine are rare and the occurrence of primary Ewing’s sarcoma in the spine is very rare.
Amine Cherraqi MD, Abir Lemrabet MD, Ibrahima Diallo Dokal MD, Najlae Lrhorfi MD, Hicham Belghiti MD, Nazik Allali PhD, Latifa Chat PhD   +6 more
doaj   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source

Primary Occipital Ewing’s Sarcoma with Subsequent Spinal Seeding

, 2017
Ewing’s sarcoma is a primary bone cancer that mainly affects the long bones. This malignancy is particularly common in pediatric patients. Primary cranial involvement accounts for 1% of cases, with occipital involvement considered extremely rare. In this
Ali Alqahtani, Eman Bakhsh, Roaa Amer
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Ewing’s sarcoma of the mobile spine: Three unusual observations

, 2019
Background. Ewing’s sarcoma is a bony highly malignant tumour, it occurs most frequently in the second decade of life. Ewing’s sarcoma is a rare affection, located usually in the pelvis, the femur, the humerus, the ribs, the mandible and clavicle, other ...
Benmedakhene, N., Berchiche, L., Assoumane, I., Bennafaa, T., Khelifa, A., Morsli, A., Bachir, S.   +6 more
core   +1 more source

Primary mediastinal Ewing’s sarcoma presenting with sudden and severe chest pain: a case report

Frontiers in Oncology
Ewing’s sarcoma, characterized by small round cell morphology, is a rare malignancy, with mediastinal Ewing’s sarcoma being even less common. This case describes a distinctive presentation of primary mediastinal Ewing’s sarcoma in a 32-year-old male ...
Chen Su, Chen Su, Xiaobo Zhu, Xiaobo Zhu, Junjie Zhang, Junjie Zhang   +5 more
doaj   +1 more source