Results 21 to 30 of about 44,634 (268)
BMC Cancer, 2022 Highlights 1. Nearly 44% of relapsed Ewing sarcoma patients achieved an ORR after IT treatment. 2. Relapsed Ewing sarcoma treated with IT had an over 66% DCR. 3.
Bi-Cheng Wang, Bo-Ya Xiao, Guo-He Lin
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Cell Genomics, 2022 Summary: Repeat elements can be dysregulated at a genome-wide scale in human diseases. For example, in Ewing sarcoma, hundreds of inert GGAA repeats can be converted into active enhancers when bound by EWS-FLI1.
Y. Esther Tak +16 more
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Germline PTPRD mutations in Ewing sarcoma: biologic and clinical implications. [PDF]
, 2013 Ewing sarcoma occurs in children, adolescents and young adults. High STAT3 levels have been reported in approximately 50% of patients with Ewing sarcoma, and may be important in tumorigenesis.
Anderson, Peter M +9 more
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CA: A Cancer Journal for Clinicians, 1976 There are no known external causes of Ewing’ sarcoma, a form of bone cancer, although a small number of cases are linked to genetic abnormalities. This malignancy occurs with remarkable consistency in registry populations across Europe and the United States, including Los Angeles County. Few cases of it occur after age 30.
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C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells. [PDF]
, 2017 CEBPB copy number gain in Ewing sarcoma was previously shown to be associated with worse clinical outcome compared to tumors with normal CEBPB copy number, although the mechanism was not characterized.
Abegglen, Lisa M +12 more
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Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]
, 2014 Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C +8 more
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Nature Reviews Disease Primers, 2018 Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of 70-80% for patients with standard-risk and localized disease and ~30% for those with metastatic disease.
Grünewald, Thomas G. P. +8 more
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SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth
Advanced Science, 2021 Chromosomal translocation results in development of an Ewing sarcoma breakpoint region 1‐Friend leukemia integration 1 (EWS–FLI1) fusion oncogene in the majority of Ewing sarcoma.
Siyuan Su +13 more
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Extraskeletal Ewing's sarcoma [PDF]
Cancer, 1999 Ewing's sarcoma usually is identified as a primary malignancy of bone affecting children and young adults. Extraskeletal Ewing's sarcoma is rare, and very few data are available addressing optimal surgical and oncologic treatment modalities.The authors chose to review retrospectively 24 patients with extraskeletal Ewing's sarcoma treated at the study ...
R, Ahmad +3 more
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EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma [PDF]
, 2018 Many cancer types are driven by oncogenic transcription factors that have been difficult to drug. Transcriptional inhibitors, however, may offer inroads into targeting these cancers.
Abraham, Brian J. +16 more
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