Results 161 to 170 of about 4,878 (253)

Network Pharmacology and Integrated Experimental Evidence Demonstrate That Ophiopogonin D Suppresses Hepatocellular Carcinoma Progression via the UCK2–SLC7A11 Axis

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
Ophiopogonin D exerts anti‐HCC effects by targeting UCK2 and inducing ferroptosis via the UCK2‐SLC7A11 axis. ABSTRACT Hepatocellular carcinoma (HCC) treatment faces significant challenges, including high toxicity and drug resistance. Ophiopogonin D, the active compound derived from the medicinal food material Ophiopogon japonicus (Mai Dong), has ...
Yuxia Hao   +7 more
wiley   +1 more source

A MICROPROPAGATION AND ACCLIMATIZATION OF LYCIUM BARBARUM L. MICROPLANTS TO EX VITRO CONDITIONS

open access: yesAgricultura
With a high content of antioxidants, vitamins, amino acids, essential minerals and essential fatty acids, goji (Lycium barbarum L.) contributes to general well-being, supports the immune system, being considered a superfood. Goji berries have a long history of medicinal use, they are considered to have an important antidiabetic, anti-aging and ...
Mihaela Cioloca   +3 more
openaire   +1 more source

Dysregulation of Non‐Muscle Myosin IIA Assembly and Phosphorylation in S100A4 Null Mouse Lens

open access: yesJournal of Cellular Physiology, Volume 241, Issue 6, June 2026.
This study identifies S100A4 as a critical regulator of NMIIA assembly, phosphorylation, and actin cytoskeletal organization in the ocular lens. Loss of S100A4 disrupts lens fiber cell architecture and impairs lens transparency, revealing a previously unrecognized role for S100A4 in maintaining lens homeostasis and structural integrity.
Rupalatha Maddala   +3 more
wiley   +1 more source

Intradiscal Cutibacterium acnes Sustains Modic Type 1‐Like Lesions Over Time in a Rat Lumbar Endplate Injury Model

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
Intradiscal C. acnes injection sustained MC1‐like lesions with persistent neutrophil sustenance in an etiology‐specific lumbar MC rat model. This suggests that patients with bacterial MC etiology may persist in painful MC1, highlighting C. acnes and neutrophils as potential targets to promote MC1‐to‐MC2 conversion and improve pain and disability ...
Irina Heggli   +12 more
wiley   +1 more source

Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus

open access: yesMicrobiologyOpen, Volume 15, Issue 3, June 2026.
A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres   +13 more
wiley   +1 more source

Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1‐STING Inflammatory Axis

open access: yesSmart Medicine, Volume 5, Issue 3, June 2026.
Magnetic fields modulate macrophage‐cancer crosstalk through the STING‐TRPC1 axis. Exposure reprograms macrophages toward the anti‐cancer phenotype. Exposing cancer cells modulates cancer secretome to promote polarization and selective recruitment of M1‐tumoricidal macrophages, enhancing cancer immunogenicity.
Viresh Krishnan Sukumar   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy