Results 21 to 30 of about 64,816 (248)

Alcohol-associated liver disease and behavioral and medical cofactors: unmet needs and opportunities

Frontiers in Public Health
Chronic liver disease is a leading cause of death in the US and is often preventable. Rising burden, cost, and fatality due to liver disease are driven by intensified alcohol use in the US population and the contributions of comorbid conditions.
Mollie A. Monnig, Mollie A. Monnig, Hayley Treloar Padovano, Hayley Treloar Padovano, Hayley Treloar Padovano, Peter M. Monti, Peter M. Monti   +6 more
doaj   +1 more source

Exacerbations of bronchiectasis

European Respiratory Review
Bronchiectasis presents a significant challenge due to its rising prevalence, associated economic burden and clinical heterogeneity. This review synthesises contemporary understanding and literature of bronchiectasis exacerbations, addressing the transition from stable state to exacerbations, underlining the importance of early and precise recognition,
Alessandro De Angelis, Emma D. Johnson, Sivagurunathan Sutharsan, Stefano Aliberti   +3 more
openaire   +5 more sources

Targeting the COPD Exacerbation

Respiratory Medicine, 2008
Exacerbations of COPD have a profound detrimental effect on the patient and impose a significant burden on healthcare resource utilization. Prevention and treatment of exacerbations are major objectives of the clinical management of COPD. For this approach to be successful, clinicians must combine both pharmacologic approaches and non-pharmacologic ...
Decramer, Marc, Nici, Linda, Nardini, Stefano, Reardon, Jane, Rochester, Carolyn L., Sanguinetti, Claudio M., Troosters, Thierry   +6 more
openaire   +4 more sources

Effectiveness of Nationwide COPD Pay-for-Performance Program on COPD Exacerbations in Taiwan

International Journal of COPD, 2021
Shih-Lung Cheng,1,2,* Yi-Rong Li,3,* Nicole Huang,4 Chong-Jen Yu,5 Hao-Chien Wang,5 Meng-Chih Lin,6 Kuo-Chin Chiu,7 Wu-Huei Hsu,8 Chiung-Zuei Chen,9 Chau-Chyun Sheu,10,11 Diahn-Warng Perng,12 Sheng-Hao Lin,13 Tsung-Ming Yang,14 Chih-Bin Lin,15 ...
Cheng SL, Li YR, Huang N, Yu CJ, Wang HC, Lin MC, Chiu KC, Hsu WH, Chen CZ, Sheu CC, Perng DW, Lin SH, Yang TM, Lin CB, Kor CT, Lin CH   +15 more
doaj  

Questions of management of patients with hard-to-treat remitting multiple sclerosis

Медицинский совет, 2015
82 patients diagnosed with remitting multiple sclerosis, (MS) undergoing treatment with fingolimod were followed up for minimum 12 months at the Moscow Multiple Sclerosis Centre. The purpose of the follow-up was to evaluate the effects of fingolimod.
E. V. Popova, M. V. Melnikov, A. N. Boiko, V. V. Murugin, M. V. Paschenkov   +4 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Acute exacerbation of COPD [PDF]

Respirology, 2016
AbstractThe literature of acute exacerbation of chronic obstructive pulmonary disease (COPD) is fast expanding. This review focuses on several aspects of acute exacerbation of COPD (AECOPD) including epidemiology, diagnosis and management. COPD poses a major health and economic burden in the Asia‐Pacific region, as it does worldwide. Triggering factors
David S.C. Hui, Fanny W.S. Ko, John R. Goddard, Ian A. Yang, Ka Pang Chan, David W. Reid, David W. Reid, Janet G. Shaw   +7 more
openaire   +4 more sources

The Characteristics of Airflow Limitation and Future Exacerbations in Different GOLD Groups of COPD Patients

International Journal of COPD, 2021
Qing Song,1– 3 Yi-Yang Zhao,1– 3 Yu-Qin Zeng,1– 3 Cong Liu,1– 3 Wei Cheng,1– 3 Min-Hua Deng,4 Xin Li,5 Li-Bing Ma,6 Yan Chen,1– 3 Shan Cai,1– 3 Ping Chen1– 3 1Department of Respiratory and Critical Care ...
Song Q, Zhao YY, Zeng YQ, Liu C, Cheng W, Deng MH, Li X, Ma LB, Chen Y, Cai S, Chen P   +10 more
doaj  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source