Results 61 to 70 of about 2,298,639 (295)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Exact algorithms for the matrix bid auction [PDF]
Computers & Operations Research, 2007 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Dries R. Goossens, Frits C. R. Spieksma
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Algorithms for the quantitative Lock/Key model of cytoplasmic incompatibility
Algorithms for Molecular Biology, 2020 Cytoplasmic incompatibility (CI) relates to the manipulation by the parasite Wolbachia of its host reproduction. Despite its widespread occurrence, the molecular basis of CI remains unclear and theoretical models have been proposed to understand the ...
Tiziana Calamoneri +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Exact Algorithms for Linear Matrix Inequalities [PDF]
SIAM Journal on Optimization, 2016 Let $A(x)=A\_0+x\_1A\_1+...+x\_nA\_n$ be a linear matrix, or pencil, generated by given symmetric matrices $A\_0,A\_1,...,A\_n$ of size $m$ with rational entries. The set of real vectors x such that the pencil is positive semidefinite is a convex semi-algebraic set called spectrahedron, described by a linear matrix inequality (LMI).
Henrion, Didier +2 more
openaire +6 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Exact Algorithms for MRE Inference
Journal of Artificial Intelligence Research, 2016 Most Relevant Explanation (MRE) is an inference task in Bayesian networks that finds the most relevant partial instantiation of target variables as an explanation for given evidence by maximizing the Generalized Bayes Factor (GBF). No exact MRE algorithm has been developed previously except exhaustive search.
Xiaoyuan Zhu, Changhe Yuan
openaire +3 more sources
An Exact Algorithm for Minimum Distortion Embedding [PDF]
Theoretical Computer Science, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Fedor V. Fomin +2 more
openaire +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source