Results 51 to 60 of about 879 (254)

Exact boundary controllability for the Boussinesq equation with variable coefficients

Evolution Equations and Control Theory, 2018
In this paper we study the exact boundary controllability for the following Boussinesq equation with variable physical parameters: \begin{array}{lll} ρ(x)y_{tt}=-(σ(x)y_{xx})_{xx}+(q(x)y_x)_x-(y^2)_{xx},&&t>0,~x\in(0,l),\\ y(t,0)=σ(l)y_{xx}(t,0)=y(t,l)=0,~~σ(l)y_{xx}(t,l)=u(t)&&t>0, \end{array} where $l>0$, the coefficients $ρ ...
Ben Amara, Jamel, Bouzidi, Hedi
openaire   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Local exact controllability of the age-dependent population dynamics with diffusion

Abstract and Applied Analysis, 2001
We investigate the local exact controllability of a linear age and space population dynamics model where the birth process is nonlocal. The methods we use combine the Carleman estimates for the backward adjoint system, some estimates in the theory of ...
Bedr'eddine Ainseba, Sebastian Anita
doaj   +1 more source

Exact boundary controllability of the plate equation

Differential and Integral Equations, 2000
This paper studies exact boundary controllability of a transmission problem for the plate equation for sufficiently large times \(T>0\). As a main tool in the proof of exact controllability, the author derives a stability result with respect to a Cauchy-type problem.
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Exact Boundary Controller Design for a Kind of Enhanced Oil Recovery Models

Abstract and Applied Analysis, 2014
The exact boundary controllability of a class of enhanced oil recovery systems is discussed in this paper. With a simple transformation, the enhanced oil recovery model is first affirmed to be neither genuinely nonlinear nor linearly degenerate.
Ping Guo, Changhua Wei, Wenjun Xiong, Chunlan Zhao   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source