Results 61 to 70 of about 879 (254)

Exact boundary controllability for a series of membranes elastically connected

Electronic Journal of Differential Equations, 2017
In this article we study the exact controllability with Neumann boundary controls for a system of linear wave equations coupled in parallel by lower order terms on piecewise smooth domains of the plane. We obtain square integrable controls for initial
Waldemar D. Bastos, Ruikson S. O. Nunes, Joao Manoel Soriano Pitot   +2 more
doaj  

Schrödinger equations in noncylindrical domains: exact controllability

International Journal of Mathematics and Mathematical Sciences, 2006
We consider an open bounded set Ω⊂ℝn and a family {K(t)}t≥0 of orthogonal matrices of ℝn. Set Ωt={x∈ℝn;x=K(t)y,for all y∈Ω}, whose boundary is Γt.
G. O. Antunes, M. D. G. da Silva, R. F. Apolaya   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Exact controllability of a second order integro-differential equation with a pressure term

Electronic Journal of Qualitative Theory of Differential Equations, 1998
This paper is concerned with the boundary exact controllability of the equation $$u''-\Delta u-\int_0^t g(t-\sigma)\Delta u(\sigma) d\sigma=-\nabla p$$ where $Q$ is a finite cilinder $\Omega\times]0,T[$, $\Omega$ is a bounded domain of $R^n$, $u=(u_1(x,t)
Marcelo Cavalcanti, V. N. D. Cavalcanti, A. Rocha, J. A. Soriano   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Convergence of the boundary control for the wave equation in domains with holes of critical size

Electronic Journal of Differential Equations, 2002
In this paper, we consider the homogenization of the exact controllability problem for the wave equation in periodically perforated domain with holes of critical size. We show that the boundary control converges to the boundary control of the homogenized
A. K. Nandakumaran
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Exact controllability problem of a wave equation in non-cylindrical domains

Electronic Journal of Differential Equations, 2015
Let $\alpha: [0, \infty)\to(0, \infty)$ be a twice continuous differentiable function which satisfies that $\alpha(0)=1$, $\alpha'$ is monotone and ...
Hua Wang, Yijun He, Shengjia Li
doaj  

Observability and uniqueness theorem for a coupled hyperbolic system

International Journal of Mathematics and Mathematical Sciences, 2000
We deal with the inverse inequality for a coupled hyperbolic system with dissipation. The inverse inequality is an indispensable inequality that appears in the Hilbert Uniqueness Method (HUM), to establish equivalence of norms which guarantees uniqueness
Boris V. Kapitonov, Joel S. Souza
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source