Results 71 to 80 of about 879 (254)

Generalized control with compact support for systems with distributed parameters

Archives of Control Sciences, 2015
We propose a generalization of the Butkovskiy's method of control with compact support [1] allowing to derive exact controllability conditions and construct explicit solutions in control problems for systems with distributed parameters.
Khurshudyan Asatur ZH.
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Internal exact controllability and uniform decay rates for a model of dynamical elasticity equations for incompressible materials with a pressure term

Electronic Journal of Qualitative Theory of Differential Equations, 2018
This paper is concerned with the internal exact controllability of the following model of dynamical elasticity equations for incompressible materials with a pressure term, $$\phi''-\Delta \phi=-\nabla p,$$ and it is also devoted to the study of the ...
Adriana Almeida, María Astudillo Rojas, Marcelo Cavalcanti, Janaina Zanchetta   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Simultaneous exact controllability for Maxwell equations and for a second-order hyperbolic system

Electronic Journal of Differential Equations, 2010
We present a result on "simultaneous" exact controllability for two models that describe two hyperbolic dynamics. One is the system of Maxwell equations and the other a vector-wave equation with a pressure term.
Boris V. Kapitonov, Gustavo Perla Menzala   +1 more
doaj  

Factor spaces and implications on Kirchhoff equations with clamped boundary conditions

Abstract and Applied Analysis, 2001
We consider mixed problems for the Kirchhoff elastic and thermoelastic systems, subject to boundary control in the clamped boundary conditions BC (clamped control).
Irena Lasiecka, Roberto Triggiani
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

L2(Σ)-regularity of the boundary to boundary operator B∗L for hyperbolic and Petrowski PDEs

Abstract and Applied Analysis, 2003
This paper takes up and thoroughly analyzes a technical mathematical issue in PDE theory, while—as a by-pass product—making a larger case. The technical issue is the L2(Σ)-regularity of the boundary → boundary operator B∗L for (multidimensional ...
I. Lasiecka, R. Triggiani
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source